Critical Care Clinics RSS feed: Articles in Press. Critical Care Clinics updates you on the latest trends in patient management; keeps you up to date on the newest advances; and provides a sound basis for choosing treatment options. Each issue focuses on a single topic in critical care and is presented under the direction of an experienced guest editor.http://www.criticalcare.theclinics.com//inpress?rss=yesElsevier Inc.en © 2007 Elsevier Inc. All rights reserved. Critical Care Clinics0749-07042009-02-06 © 2007 Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.criticalcare.theclinics.com/article/PIIS0749070407000498/abstract?rss=yesIn the April 2007 issue of Critical Care Clinics, Volume 23, Number 2, in Dr. Victoria E. Johnson's article, “Special Cases: Mechanical Ventilation of Neurosurgical Patients” starting on page 275, an error was made in the section titled “Hyperventilation as a Therapy”. On page 282 the sentence should read, “Hyperventilation results in a decrease in blood CO2 level.”Erratum - Corrected Proof10.1016/j.ccc.2007.07.008Critical Care Clinics (2009)2009-02-06Critical Care Clinics2009-02-06http://www.criticalcare.theclinics.com/article/PIIS0749070407000966/abstract?rss=yesThe relationship between systemic illness and neurobehavioral changes is both undisputed and poorly understood. Who has not experienced the somnolence, anorexia, fatigue, and social withdrawal that accompany fever and infection? Yet this “malaise” or “sickness behavior,” which is linked to the action of proinflammatory cytokines in the brain , is just one component in a sophisticated set of responses triggered in the central nervous system by systemic disease. The breadth and complexity of these responses is beginning to unravel thanks to a growing body of experimental and clinical research, and traditional paradigms of the central nervous system as a “privileged” organ have undergone extensive reevaluation . New data reveal that the brain and extracerebral organs talk to each other in a bidirectional fashion, not only through afferent and efferent neural arcs but by way of physiologic, metabolic, immunologic, and endocrine signaling mechanisms . The articles appearing in this issue of Critical Care Clinics suggest that the ICU is a unique arena to elucidate this cross-talk, to test hypotheses as to its mechanisms, and to develop strategies for modulating it to therapeutic ends.Preface - Corrected ProofRobert D. Stevens10.1016/j.ccc.2007.12.001Critical Care Clinics (2009)2009-02-06Critical Care Clinics2009-02-06