Over the past 30 years, remarkable progress has been made in improving outcome from
traumatic brain injury (TBI). Overall mortalities from severe TBI have dropped from
in the range of 36% in the late 1980s into the low-to-middle teens at specialized
TBI centers [
1
,
2
]. Although many etiologies for such improvement have been suggested, it is unclear
what changes actually affected the improvement in outcome. Despite the fervor for
laboratory investigations of TBI models, it is sobering to recognize that no treatments
have come from bench to bedside. As such, there are no magic bullets in the treatment
of central nervous system (CNS) trauma in general, and TBI in particular. Instead,
it appears to be a combination of many improvements in brain injury care, trauma systems,
and critical care that has produced the decrease in mortality.To read this article in full you will need to make a payment
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