Widespread concern about complications associated with red blood cell (RBC) transfusions
has led to the scrutiny of traditional transfusion practices. Recently, attempts have
been made to evaluate the efficacy of RBC transfusion and to thereby define more clearly
the indications for RBC transfusions in patients, particularly those who are critically
ill.
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References
- A multi-center, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.N Engl J Med. 1999; 340: 409-417
- ABC (Anemia and Blood Transfusion in Critical Care) Investigators. Anemia and blood transfusion in critically ill patients.JAMA. 2002; 288: 1499-1507
- Anemia and blood transfusion in the critically ill: current clinical practice in the United States—The CRIT Study.Crit Care Med. 2004; 32: 39-52
- Transfusion requirements in Critical Care Investigators for the Canadian Critical Care Trials Group. Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?.Crit Care Med. 2001; 29: 227-234
- Transfusion requirements in Critical Care Investigators for the Canadian Critical Care Trials Group. Do blood transfusions improve outcomes related to mechanical ventilation?.Chest. 2001; 119: 1850-1857
- Effects of transfusion on immune function.Arch Pathol Lab Med. 1994; 118: 371-379
- Blood transfusion-induced immunomodulation.Anesth Analg. 1996; 82: 187-204
- The immunosuppressive aspects of blood transfusion.J Intensive Care Med. 1992; 7: 176-188
- Immunomodulation and blood transfusion.Am J Ther. 2002; 9: 389-395
- Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis.J Trauma. 2003; 54: 908-914
- Impact of allogenic packed red blood cell transfusion on nosocomial infection rates in the critically ill patient.Crit Care Med. 2002; 30: 2249-2254
- Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction.Blood. 2001; 97: 1180-1195
- Universal WBC reduction: the case for and against.Transfusion. 2001; 41: 691-712
- Perioperative allogeneic blood transfusion does not cause adverse sequelae in patients with cancer: a meta-analysis of unconfounded studies.Br J Surg. 1998; 85: 171-178
- Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions.JAMA. 2003; 289: 1941-1949
- A prospective, randomized clinical trial of universal WBC reduction.Transfusion. 2002; 42: 1114-1122
- Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients.Chest. 1992; 102: 208-215
- Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma.J Trauma. 1995; 38: 780-787
- Endpoints of resuscitation of critically injured patients: normal or supranormal? A prospective randomized trial.Ann Surg. 2000; 232: 409-418
- Meta-analysis of hemodynamic optimization in high-risk patients.Crit Care Med. 2002; 30: 1686-1692
- A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock.Chest. 1999; 115: 453-461
- A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group.N Engl J Med. 1995; 333: 1025-1032
- Maximizing oxygen delivery in critically ill patients: a methodologic appraisal of the evidence.Crit Care Med. 1996; 24: 517-524
- Failure of red blood cell transfusion to increase oxygen transport or mixed venous PO2 in injured patients.J Trauma. 1982; 22: 741-746
- Hemodynamic oxygen transport and 2,3-diphosphoglycerate changes after transfusion of patients in acute respiratory failure.Intensive Care Med. 1986; 12: 22-25
- Effect of transfusion on oxygen transport in critically ill patients.Shock. 1996; 5: 190-193
- Effect of blood transfusion on oxygen consumption in pediatric septic shock.Crit Care Med. 1990; 18: 1087-1091
- Cardiovascular and metabolic response to red blood cell transfusion in critically ill volume-resuscitated nonsurgical patients.Crit Care Med. 1990; 18: 940-944
- Reevaluation of current transfusion practices in patients in surgical intensive care units.Am J Surg. 1992; 164: 22-25
- Effects of blood transfusion on oxygen transport variables in severe sepsis.Crit Care Med. 1993; 21: 1312-1318
- Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients.Crit Care. 2001; 5: 362-367
- Effect of red cell transfusion on oxygen consumption following fluid resuscitation in septic shock.Circ Shock. 1990; 31: 419-429
- Blood transfusion and oxygen consumption in surgical sepsis.Crit Care Med. 1991; 19: 512-517
- Factors influencing the individual effects of blood transfusions on oxygen delivery and oxygen consumption.Crit Care Med. 1999; 27: 2194-2200
- Evaluation of oxygen extraction ratio as a physiologic transfusion trigger in coronary artery bypass graft surgery patients.Transfusion. 2001; 41: 591-595
- Gastric tonometry in patients with sepsis. Effects of dobutamine infusions and packed red blood cell transfusions.Chest. 1992; 102: 184-188
- Regional blood flow and oxygen transport in patients with the low cardiac output syndrome after cardiac surgery.Crit Care Med. 1993; 21: 1304-1311
- Effect of stored blood transfusion on oxygen delivery in patients with sepsis.JAMA. 1993; 269: 3024-3029
- Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats.Crit Care Med. 1997; 25: 726-732
- Influence of storage on red blood cell rheological properties.J Surg Res. 2002; 102: 6-12
- A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion.Transfus Med. 2000; 10: 291-303
- Alteration of red cell aggregability and shape during blood storage.Transfusion. 1999; 39: 277-281
- Hemolysis in stored red blood cell concentrates: modulation by haptoglobin or ulinastatin, a protease inhibitor.Crit Care Med. 2001; 29: 1979-1982
- Hemoglobin and the paracrine and endocrine functions of nitric oxide. Clinical implications of basic research.N Engl J Med. 2003; 348: 1483-1485
- Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.Nat Med. 2002; 8: 1383-1389
- Blood transfusion. An independent risk factor for postinjury multiple organ failure.Arch Surg. 1997; 132 (discussion 624–5): 620-624
- Blood transfusion, independent of shock severity, is associated with worse outcome in trauma.J Trauma. 2003; 54 (discussion 905–7): 898-905
- Age of transfused blood is an independent risk factor for postinjury multiple organ failure.Am J Surg. 1999; 178: 570-572
- Stored red blood cells selectively activate human neutrophils to release IL-8 and secretory PLA2.Shock. 2000; 13: 29-33
- WBC reduction reduces storage-associated RBC adhesion to human vascular endothelial cells under conditions of continuous flow in vitro.Transfusion. 2003; 43: 151-156
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© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
