Many of the physiological concepts in oxygen (O2) transport and use were described in the early part of the 20th century and are still widely accepted [
[1]
]. In 1920, Barcroft [
[2]
] noted that tissue oxygenation was a function of hemoglobin concentration, oxygenation
of blood by the lungs, and the cardiac output to deliver a supply of oxygenated blood
to the tissues. Similarly, many of the principles underlying the transfer of O2 from the microcirculation to the mitochondria have been established and also have
stood the test of time [
[1]
]. This article describes some of the basic principles of O2 transport that have been studied extensively and published in text books and review
articles [
1
,
3
,
4
,
5
]. It emphasizes the physiological consequences of anemia to provide information relevant
to red cell transfusion decisions.To read this article in full you will need to make a payment
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Article info
Footnotes
☆Dr. Hébert is an Ontario Ministry of Health Career Scientist.
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© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
