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Review Article| Volume 20, ISSUE 3, P435-451, July 2004

Principles and practice of withdrawing life-sustaining treatments

      Most deaths in intensive care units occur after decisions to limit or withdraw life support [
      • Vincent J.L
      • Parquier J.N
      • Preiser J.C
      • Brimioulle S
      • Kahn R.J
      Terminal events in the intensive care unit: review of 258 fatal cases in one year.
      ,
      • Prendergast T.J
      • Luce J.M
      Increasing incidence of withholding and withdrawal of life support from the critically ill.
      ]. Despite an extensive literature on whether to withdraw life support, little attention has been given to how to withdraw it [
      • Grenvik A
      Terminal weaning”; discontinuance of life-support therapy in the terminally ill patient.
      ,
      • Faber-Langendoen K
      • Bartels D.M
      Process of forgoing life-sustaining treatment in a university hospital: an empirical study.
      ]. For example, a recent edition of a critical care textbook exhaustively covers the ethical and legal aspects of life-support withdrawal, but makes no recommendations for carrying it out [
      • Hall J
      • Schmidt G
      • Wood L
      ]. Only recently, in the wake of growing data that problems may exist in providing palliative care in the intensive care unit (ICU), has attention been directed to the practical aspects of withdrawing life support [
      • Brody H
      • Campbell M.L
      • Faber-Langendoen K
      • Ogle K.S
      Withdrawing intensive life-sustaining treatment—recommendations for compassionate clinical management.
      ,
      ,
      • Campbell M.L
      ]. Many practical questions about withdrawal of life support, and specifically about the withdrawal of mechanical ventilation, are perplexing and controversial: Should the endotracheal tube be left in place? Should the ventilator be weaned slowly or quickly? When and how should sedation be increased? How can the concerns about relieving suffering be reconciled with fears of killing the patient? Should neuromuscular blockade be discontinued? These questions are important because clinicians face them frequently and are still confused by the goals and process of withdrawing life support, and because patients who die after withdrawal of life support may receive inadequate pain and symptom management [
      • Asch D.A
      The role of critical care nurses in euthanasia and assisted suicide.
      ,
      A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators.
      ].
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      References

        • Vincent J.L
        • Parquier J.N
        • Preiser J.C
        • Brimioulle S
        • Kahn R.J
        Terminal events in the intensive care unit: review of 258 fatal cases in one year.
        Crit Care Med. 1989; 17: 530-533
        • Prendergast T.J
        • Luce J.M
        Increasing incidence of withholding and withdrawal of life support from the critically ill.
        Am J Respir Crit Care Med. 1997; 155: 15-20
        • Grenvik A
        Terminal weaning”; discontinuance of life-support therapy in the terminally ill patient.
        Crit Care Med. 1983; 11: 394-395
        • Faber-Langendoen K
        • Bartels D.M
        Process of forgoing life-sustaining treatment in a university hospital: an empirical study.
        Crit Care Med. 1992; 20: 570-577
        • Hall J
        • Schmidt G
        • Wood L
        Principles of critical care. McGraw-Hill, New York1992
        • Brody H
        • Campbell M.L
        • Faber-Langendoen K
        • Ogle K.S
        Withdrawing intensive life-sustaining treatment—recommendations for compassionate clinical management.
        N Engl J Med. 1997; 336: 652-657
      1. Curtis J.R Rubenfeld G.D Managing death in the ICU: the transition from cure to comfort. Oxford University Press, New York2000
        • Campbell M.L
        Forgoing life-sustaining therapy: how to care for the patient who is near death. AACN Critical Care, Aliso Viejo (CA)1998
        • Asch D.A
        The role of critical care nurses in euthanasia and assisted suicide.
        N Engl J Med. 1996; 334: 1374-1379
      2. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT). The SUPPORT Principal Investigators.
        JAMA. 1995; 274: 1591-1598
      3. Withholding and withdrawing life-sustaining therapy. This Official Statement of the American Thoracic Society was adopted by the ATS Board of Directors, March 1991.
        Am Rev Respir Dis. 1991; 144: 726-731
        • Lo B
        Resolving ethical dilemmas: a guide for clinicians. Williams & Wilkins, Baltimore1995
        • Jonsen A.R
        • Siegler M
        • Winslade W.J
        Clinical ethics: a practical approach to ethical decisions in clinical medicine. 4th edition. McGraw Hill, New York1998
        • Faber-Langendoen K
        A multi-institutional study of care given to patients dying in hospitals. Ethical and practice implications.
        Arch Intern Med. 1996; 156: 2130-2136
        • Beauchamp T.L
        • Childress J.F
        Principles of biomedical ethics. 4th edition. Oxford University Press, New York1994
        • Asch D.A
        • Hansen F.-J
        • Lanken P.N
        Decisions to limit or continue life-sustaining treatment by critical care physicians in the United States: conflicts between physicians' practices and patients' wishes.
        Am J Respir Crit Care Med. 1995; 151: 288-292
        • Wachter R.M
        • Luce J.M
        • Hearst N
        • Lo B
        Decisions about resuscitation: inequities among patients with different diseases but similar prognoses.
        Ann Intern Med. 1989; 111: 525-532
        • Cook D.J
        • Guyatt G.H
        • Jaeschke R
        • Reeve J
        • Spanier A
        • King D
        • et al.
        Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill.
        JAMA. 1995; 273: 703-708
        • Hanson L.C
        • Danis M
        • Garrett J.M
        • Mutran E
        Who decides? Physicians' willingness to use life-sustaining treatment.
        Arch Intern Med. 1996; 156: 785-789
        • Truog R.D
        • Brett A.S
        • Frader J
        The problem with futility.
        N Engl J Med. 1992; 326: 1560-1564
        • Prendergast T.J
        • Claessens M.T
        • Luce J.M
        A national survey of end-of-life care for critically ill patients.
        Am J Respir Crit Care Med. 1998; 158: 1163-1167
        • Diem S.J
        • Lantos J.D
        • Tulsky J.A
        Cardiopulmonary resuscitation on television. Miracles and misinformation.
        N Engl J Med. 1996; 334: 1578-1582
        • Campbell M.L
        • Bizek K.S
        • Thill M
        Patient responses during rapid terminal weaning from mechanical ventilation: a prospective study.
        Crit Care Med. 1999; 27: 73-77
        • Shapiro B.A
        • Warren J
        • Egol A.B
        • et al.
        Practice parameters for intravenous analgesia and sedation for adult patients in the intensive-care unit—an executive summary.
        Crit Care Med. 1995; 23: 1596-1600
        • Truog R.D
        • Berde C.B
        • Mitchell C
        • Grier H.E
        Barbiturates in the care of the terminally ill.
        N Engl J Med. 1992; 327: 1678-1682
        • Solomon M.Z
        • O'Donnell L
        • Jennings B
        • et al.
        Decisions near the end of life: professional views on life-sustaining treatments.
        Am J Public Health. 1993; 83: 14-23
        • Christakis N.A
        • Asch D.A
        Biases in how physicians choose to withdraw life support.
        Lancet. 1993; 342: 642-646
        • Christakis N.A
        • Asch D.A
        Medical specialists prefer to withdraw familiar technologies when discontinuing life support.
        J Gen Intern Med. 1995; 10: 491-494
        • Gianakos D
        Terminal weaning.
        Chest. 1995; 108: 1405-1406
        • President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research
        Deciding to forego life-sustaining treatment. US Government Printing Office, Washington (DC)1983
        • Campbell M.L
        Case studies in terminal weaning from mechanical ventilation.
        Am J Crit Care. 1993; 2: 354-358
      4. Treece P.D., Engelberg R.A., Crowley L., et al. Evaluation of a standardized order form for the withdrawal of life support in the intensive care unit. Crit Care Med 2004; in press

        • Benditt J.O
        Noninvasive ventilation at the end of life.
        Respir Care. 2000; 45 (discussion 1381–74): 1376-1381
        • Wilson W.C
        • Smedira N.G
        • Fink C
        • McDowell J.A
        • Luce J.M
        Ordering and administration of sedatives and analgesics during the withholding and withdrawal of life support from critically ill patients.
        JAMA. 1992; 267: 949-953
        • Mayer S.A
        • Kossoff S.B
        Withdrawal of life support in the neurological intensive care unit.
        Neurology. 1999; 52: 1602-1609
        • Kirkland L
        Neuromuscular paralysis and withdrawal of mechanical ventilation.
        J Clin Ethics. 1994; 5 (discussion 39–42): 38-39
        • Truog R.D
        • Burns J.P
        • Mitchell C
        • Johnson J
        • Robinson W
        Pharmacologic paralysis and withdrawal of mechanical ventilation at the end of life.
        N Engl J Med. 2000; 342: 508-511
        • Segredo V
        • Caldwell J.E
        • Matthay M.A
        • Sharma M.L
        • Gruenke L.D
        • Miller R.D
        Persistent paralysis in critically ill patients after long-term administration of vecuronium.
        N Engl J Med. 1992; 327: 524-528