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Review Article| Volume 20, ISSUE 4, P697-712, October 2004

Spectrum of hypertensive emergencies in pregnancy

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      References

        • August P.
        • Lindheimer M.D.
        Pathophysiology of preeclampsia.
        Hypertension. 1995; 142: 2407-2426
        • Dafnis E.
        • Sabatini S.
        The effect of pregnancy on renal function: physiology and pathophysiology.
        Am J Med Sci. 1992; 303: 184-205
        • Sibai B.M.
        Chronic hypertension in pregnancy.
        Obstet Gynecol. 2002; 100: 369-377
        • Wilson B.J.
        • Watson M.S.
        • Prescott G.J.
        • Sunderland S.
        • Campbell D.M.
        • Hannaford P.
        • et al.
        Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study.
        BMJ. 2003; 326: 1-7
        • Winkel C.A.
        • Milewich L.
        • Parker C.R.
        • Grant N.F.
        • Simpson E.R.
        • MacDonald P.C.
        • et al.
        Conversion of plasma progesterone to desoxycorticosterone in men, nonpregnant and pregnant women and adrenalectomized subjects.
        J Clin Invest. 1980; 66: 803-812
        • Longo L.D.
        • Hardesty J.S.
        Maternal blood volume: measurement, hypothesis of control, and clinical considerations.
        Rev Perinatal Med. 1984; 5: 35-43
        • Robson S.C.
        • Hunter S.
        • Boys R.J.
        • Dunlop W.
        Serial study of factors influencing changes in cardiac output during human pregnancy.
        Am J Physiol. 1989; 256: H1060-H1065
        • Redman C.W.G.
        Hypertension in pregnancy.
        in: Swales J.D. Textbook of hypertension. Blackwell Science, London1994: 767-784
        • Ferrer R.L.
        • Sibai B.M.
        • Murlow C.D.
        • Chiquette E.
        • Stevens K.R.
        • Cornell J.
        Management of mild chronic hypertension during pregnancy: a review.
        Obstet Gynecol. 2000; 96: 849-860
        • Keith Jr, J.C.
        • Thatcher C.D.
        • Schaub R.G.
        Beneficial effects of U-63, 557A, a thromboxane synthetase inhibitor, in an ovine model of pregnancy-induced hypertension.
        Am J Obstet Gynecol. 1987; 157: 199-203
        • Bachmann S.
        • Mundel P.
        NO in the kidney: synthesis, localization and function.
        Am J Kidney Dis. 1994; 24: 112-129
        • Seligman S.P.
        • Buyon J.P.
        • Clancy R.M.
        • Young B.K.
        • Abramson S.B.
        The role of nitric oxide in the pathogenesis of preeclamsia.
        Am J Obstet Gynecol. 1994; 171: 944-948
        • Granger J.P.
        • Alexander B.T.
        Abnormal pressure natriuresis in hypertension: role of nitric oxide.
        Acta Physiol Scand. 2000; 168: 161-168
        • Opsjon S.L.
        • Austgulen R.
        • Waage A.
        Interlukin-1, interlukin-6 and tumor necrosis factor at delivery in preeclamptic disorders.
        Acta Obstet Gynecol Scand. 1995; 74: 19-26
        • Clark B.A.
        • Halvorson L.
        • Sachs B.
        • Epstein F.H.
        Plasma endothelin levels in preeclampsia: elevation and correlation with uric acid levels and renal impairment.
        Am J Obstet Gynecol. 1992; 166: 962-968
        • Takeda-Matsubara Y.
        • Matsubara K.
        • Ochi H.
        • Masaharu I.
        • Iwai M.
        • Horiuchi M.
        Expression of endothelial angiotensin II receptor mRNA in pregnancy-induced hypertension.
        Am J Hypertens. 2003; 16: 993-999
        • Vince G.S.
        • Starkey P.M.
        • Austgulen R.
        • Kwiatkowski D.
        • Redman C.W.G.
        Interlukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia.
        Br J Obstet Gynaecol. 1995; 102: 20-25
        • Zafirovska K.G.
        • Maleska V.T.
        • Bogdanovska S.V.
        • Lozance L.A.
        • Masin-Paneva M.
        • Gerasimovska B.D.
        Plasma atrial natriuretic peptide, endothelin-1, aldosterone and plasma-renin activity in pregnancy-induced hypertension.
        J Hypertens. 1999; 17: 1317-1322
        • Gant N.F.
        • Daley G.L.
        • Chand S.
        • Whalley P.J.
        • McDonald P.C.
        A study of angiotensin II pressor response throughout primigravid pregnancy.
        J Clin Invest. 1973; 52: 2682-2689
        • Horstkamp B.S.
        • Kiess H.
        • Kramer J.
        • Riess H.
        • Henrich W.
        • Dudenhausen J.W.
        Activated protein C resistance shows an association with pregnancy-induced hypertension.
        Hum Reprod. 1999; 14: 3112-3115
        • Catalano P.M.
        • Tyzbir E.D.
        • Wolfe R.R.
        • Calles J.
        • Roman N.M.
        • Amini S.B.
        • et al.
        Carbohydrate metabolism during pregnancy in control subjects and in women with gestational diabetes.
        Am J Physiol. 1993; 264: E60-E67
        • Bryson C.L.
        • Ioannou G.N.
        • Rulyak S.J.
        • Critchlow C.
        Association between gestational diabetes and pregnancy-induced hypertension.
        Am J Epidemiol. 2003; 158: 1148-1153
        • Kjos S.L.
        • Buchanan T.A.
        Gestational diabetes.
        N Engl J Med. 1999; 341: 1749-1756
        • Solomon C.G.
        • Willett W.C.
        • Carey V.J.
        • Rich-Edwards J.
        • Hunter D.J.
        • Colditz G.A.
        • et al.
        A prospective study of pregravid determinants of gestational diabetes mellitus.
        JAMA. 1997; 278: 1078-1083
        • Ritchie L.D.
        • King J.C.
        Dietary calcium and pregnancy induced hypertension: is there a relation?.
        Am J Clin Nutr. 2000; 71: 1371-1374
      1. Report of the national high blood pressure education program: Working Group Report on High Blood Pressure in Pregnancy.
        Am J Obstet Gynecol. 2000; 183: S1-S22
        • Sibai B.M.
        • Anderson G.D.
        Pregnancy outcome of intensive therapy in severe hypertension in first trimester of pregnancy.
        Obstet Gynecol. 1986; 67: 517-522
        • Rey E.
        • Couturier A.
        The prognosis of pregnancy in women with chronic hypertension.
        Am J Obstet Gynecol. 1994; 171: 410-416
        • Jain L.
        Effect of pregnancy-induced and chronic hypertension on pregnancy outcome.
        J Perinatol. 1997; 17: 425-427
        • Svenningsen N.W.
        • Liedholm H.
        • Aberg A.
        Hypertension in pregnancy and the infant: a controlled follow-up study.
        Acta Obstet Gynecol Scand Suppl. 1984; 118: 103-106
        • Sibai B.M.
        • Lindheimer M.
        • Hauth J.
        • Caritis S.
        • Van-Dorsten P.
        • Klebanoff M.
        • et al.
        Risk factors for preeclampsia, abruption placentae, and adverse neonatal outcomes among women with chronic hypertension.
        N Engl J Med. 1998; 339: 667-671
        • Keely E.
        Endocrine causes of hypertension in pregnancy: when to start looking for Zebras.
        Semin Pernatal. 1998; 22: 471
        • Safian R.D.
        • Texter S.C.
        Renal-artery stenosis.
        N Engl J Med. 2001; 344: 431
        • Plouin P.F.
        • Breart G.
        • Maillard F.
        • Papiernik E.
        • Relier J.P.
        Comparison of the antihypertensive efficacy and prenatal safety of Labatolol and methyldopa in the treatment of hypertension in pregnancy: a randomized control trial.
        Br J Obstet Gyneacol. 1988; 95: 868-876
        • Sibai B.M.
        Diagnosis and management of gestational hypertension and preeclampsia.
        Obstet Gynecol. 2003; 102: 181-192
        • Mabie W.C.
        • Gonzaler A.R.
        • Sibai B.M.
        • Amon E.
        A comparative trial of labetolol and hydralazine in the acute management of severe hypertension complicating pregnancy.
        Obstet Gynecol. 1987; 70: 328-333
        • Vink G.J.
        • Moodley J.
        • Philpott R.H.
        Effect of hydralazine on the fetus in the treatment of maternal hypertension.
        Obstet Gynecol. 1980; 55: 519-522
        • Magee L.A.
        • Elran E.
        • Bull S.B.
        • Logan A.
        • Koren G
        Risks and benefits of β receptor blockers for pregnancy hypertension: overview of the randomized trials.
        Eu J Obstet Gynecol Reprod Biol. 2000; 88: 15-26
        • Paren E.
        • Holzberg G.
        • Zmora E.
        • Insler V.
        β Adrenargic blocking agents in the treatment of pregnancy-induced hypertension.
        Int J Clin Pharmacol Ther. 1995; 33: 519-522
        • Marlettini M.G.
        • Crippa S.
        • Morselli-Lobote A.M.
        • Contrarini A.
        • Orlandi C.
        Randomized comparison of calcium antagonists and beta-blockers in the treatment of pregnancy induced hypertension.
        Curr Ther Res. 1995; 48: 684-689
        • Janet D.
        • Carbonne B.
        • Sebban E.
        • Millez J.
        Nicardopine vs metaprolol in the treatment of hypertension during pregnancy: a randomized comparitive trial.
        Obstet Genecol. 1994; 84: 354-359
        • Pryde P.G.
        • Sedman A.B.
        • Nugent C.E.
        • Barr Jr, M.
        Angiotensin converting enzyme inhibitor fetopathy.
        J Am Soc Nephrol. 1993; 3: 1575-1582
        • Shotan A.
        • Widerhorn J.
        • Hurst A.
        • Elkayam U.
        Risks of angiotensin-converting enzyme inhibition during pregnancy: experimental and clinical evidence, potential mechanisms, and recommendations for use.
        Am J Med. 1994; 96: 451-456
        • Magee L.A.
        • Ornstein M.P.
        • von Dalelszen P.
        Fortnightly review: management of hypertension in pregnancy.
        BMJ. 1999; 318: 1322-1336
        • Bolte A.C.
        • Van Geijn H.P.
        • Dekker G.A.
        Pharmacological treatment of severe hypertension in pregnancy and the role of serotonin2-receptor blockers.
        Eu J Obstet Gynecol Reprod Biol. 2001; 95: 22-36
        • Middlekoop C.M.
        • Dekker G.A.
        • Kraayenbrink A.A.
        • Popp-Snijders C.
        Platelet poor plasma serotonin in normal and preeclamptic pregnancy.
        Clin Chem. 2001; 39: 1675-1678
        • Ferrer R.L.
        • Sibai B.M.
        • Murlow C.D.
        • Chiquette E.
        • Stevens K.R.
        • Cornell J.
        Management of mild chronic hypertension during pregnancy: a review.
        Obstet Gynecol. 2000; 96: 849-860
        • Lain K.Y.
        • Roberts J.M.
        Contemporary concepts of the pathogenesis and management of preeclampsia.
        JAMA. 2001; 287: 3183
        • Meekins J.W.
        • Pijnenborg R.
        • Hanssens M.
        • McFodjen I.R.
        • Van Asshe A.
        A study of placental bed spiral arteries and trophoblast invasion in normal and pre-eclamptic pregnancies.
        Br J Obstet Gynecol. 1994; 101: 669-674
        • Cross J.C.
        • Werb Z.
        • Fisher S.J.
        Implantation of the placenta: key pieces of the development puzzle.
        Science. 1994; 266: 1508
        • Zhou Y.
        • Damsky C.H.
        • Fisher S.J.
        Preeclampsia is associated with failure of human trophoblast to mimic a vascular adhesion phenotype: one cause of defective endovascular invasion in this syndrome.
        J Clin Invest. 1997; 99: 2152-2164
        • Arngrimsson R.
        • Sigurard T.R.
        • Frigge M.L.
        • Bjornad R.I.
        • Jonsson T.
        • Stefansson H.
        • et al.
        A genome-wide scan reveals a maternal susceptibility locus for preeclampsia on chromosome 2p13.
        Hum Mol Genet. 1999; 8: 1799
        • Moses E.K.
        • Lade J.A.
        • Guo G.
        • Wilton A.N.
        • Grehan M.
        • Freed K.
        • et al.
        A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for preeclampsia on chromosome 2.
        Am J Human Genet. 2000; 67: 1581-1585
        • Lachmeijer A.M.
        • Arngrimsson R.
        • Bastiaans E.J.
        • Frigge M.L.
        • Pals G.
        • Sigurdardottir S.
        • et al.
        A genome-wide scan for preeclampsia in the Netherlands.
        Eur J Hum Genet. 2001; 9: 758-764
        • Maynard S.E.
        • Min J.Y.
        • Marchan J.
        • Lin K.H.
        • Li J.
        • Mondal S.
        • et al.
        Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.
        J Clin Invest. 2003; 111: 649-658
        • Sibai B.M.
        • Gordon T.
        • Thom E.
        • Curtis S.N.
        • Klebanoff M.
        • McNellis D.
        • et al.
        Risk factors for preeclampsia in healthy nulliparous women: a prospective multicenter study. The National Institutes of Child Health and Human Development Network of Maternal and Fetal Medicine Units.
        Am J Obstet Gynecol. 1995; 172: 642-648
        • Sibai B.M.
        • Ewell R.J.
        • Levine R.J.
        • Klebanoff M.
        • Esterlitz J.
        • Catalano P.M.
        • et al.
        Risk factors associated with preeclampsia and eclampsia in healthy nulliparous women.
        Am J Obstet Gynecol. 1997; 177: 1003-1010
        • Zhang J.
        • Mark A.K.
        • Levine R.J.
        • Puri M.
        • Moyer P.
        The puzzling association between smoking and hypertension during pregnancy.
        Am J Obstet Gynecol. 1999; 181: 1407-1413
        • England J.L.
        • Levine R.J.
        • Qian C.
        • Morris C.D.
        • Sibai B.M.
        • Catalano P.M.
        • et al.
        Smoking before pregnancy and risk of gestational hypertension and preeclampsia.
        Am J Obstet Gynecol. 2002; 186: 1035-1040
        • Ananth C.V.
        • Bowes W.A.
        • Savitz D.A.
        • Luther E.R.
        Relationship between pregnancy induced hypertension and placenta previa: a population based study.
        Am J Obstet Gynecol. 1997; 177: 997-1002
        • Page E.W.
        • Christenson R.
        Influence of blood pressure changes with and without proteinuria upon outcome of pregnancy.
        Am J Obstet Gynecol. 1976; 166: 821-833
        • Ferrazanni S.
        • Caruso A.
        • De Carolis S.
        • Martino I.V.
        • Mancuso S.
        Proteinuria and outcome of 444 pregnancies complicated by hypertension.
        Am J Obstet Gynecol. 1990; 162: 366-371
        • Ginsburg J.M.
        • Chang B.S.
        • Matarese R.A.
        • Garella S.
        Use of single voided urine samples to estimate quantitative proteinuria.
        N Engl J Med. 1983; 309: 1543-1546
        • Robert M.
        • Sapandj F.
        • Liston R.M.
        • Dooley K.C.
        Random protein-creatine ratio for the quantification of proteinuria in pregnancy.
        Obstet Gynecol. 1997; 90: 893-895
        • Rodriguez-Thompson D.
        • Lieberman E.S.
        Use of a random protein-to-creatinine ratio for the diagnosis of significant proteinuria during pregnancy.
        Am J Obstet Gynecol. 2001; 185: 808
        • Morris M.C.
        • Twickler D.M.
        • Hatab M.R.
        • Clark G.O.
        • Peshock R.M.
        • Cunningham F.G.
        Cerebral blood flow and cranial magnetic resonance imaging in eclampsia and severe preeclampsia.
        Obstet Gynecol. 1997; 89: 561-568
        • American College of Obstetricians and Gynecologists
        Diagnosis and management of preeclampsia and eclampsia. ACOG practice bulletin #33. American College of Obstetricians and Gynecologists, Washington (DC)2002
        • American College of Obstetricians and Gynecologists
        Chronic hypertension in pregnancy. ACOG technical bulletin #29. American College of Obstetricians and Gynecologists, Washington (DC)2001
        • Magee L.A.
        • Schick B.
        • Donnenfeld A.E.
        • Sage S.R.
        • Conover B.
        • Cook L.
        The safety of calcium channel blockers in human pregnancy: a prospective multicenter cohort study.
        Am J Obstet Gynecol. 1996; 174: 823-828
        • von Dadelszen P.
        • Ornstein M.P.
        • Bull S.B.
        • Logan A.G.
        • Koren G.
        • Magee L.A.
        Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis.
        Lancet. 2000; 355: 87-92
        • Witlin A.G.
        • Sibai B.M.
        Magnesium sulfate therapy in preeclampsia and eclampsia.
        Obstet Gynecol. 1998; 92: 883-889
        • Lucas M.J.
        • Leveno K.J.
        • Cunningham F.G.
        A comparison of magnesium sulfate and phenytoin for the prevention of eclampsia.
        N Engl J Med. 1995; 333: 201-204
      2. Do women with preeclampsia and their babies, benefit from magnesium sulfate? The Magpie trial: a randomized placebo controlled trial.
        Lancet. 2002; 359: 1877-1890
        • Polley L.S.
        Anesthetic management of hypertension in pregnancy.
        Clin Obstet Gynecol. 2003; 46: 688-699
      3. Working group report on high blood pressure in pregnancy. National Institutes of Health, Washington (DC)2000
        • Alexander J.
        • Cueller R.E.
        • van Thiel D.H.
        Toxemia of pregnancy and the liver.
        Semin Liver Dis. 1987; 7: 55-58
        • Sibai B.M.
        The HELLP syndrome (hemolysis, elevated liver enzymes and low platlets): much ado about nothing?.
        Am J Obstet Gynecol. 1990; 162: 311-316
        • Yu M.
        • Nardella A.
        • Pechet L.
        Screening tests of disseminated intravascular coagulation: guidelines for rapid and specific laboratory diagnosis.
        Crit Care Med. 2000; 28: 1777-1780
        • Mabie M.C.
        • Sibai B.M.
        Transient diabetes insipidus in a patient with preeclampsia and HELLP syndrome.
        in: Cefalo R.C. Clinical decisions in obstetrics and gynecology. Aspen, Rockville (MD)1990: 136-138
        • Martin Jr, J.R.
        • Perry Jr, K.G.
        • Blake P.G.
        • et al.
        Better maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome.
        Am J Obstet Gynecol. 1997; 177: 1011-1016
        • Isler C.M.
        • Barrilleaux P.S.
        • Magnann E.F.
        • Bass J.O.
        • Martin Jr, J.N.
        A prospective randomized trial comparing the efficacy of dexamethasone and betamethasone for the treatment of antepartum HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome.
        Am J Obstet Gynecol. 2001; 184: 1332-1337
        • Martin Jr, J.N.
        • Thigpen B.D.
        • Rose C.H.
        • Cushman J.
        Maternal benefit of high dose intravenous corticosteroid therapy for HELLP syndrome.
        Am J Obstet Gynecol. 2003; 189: 830-834
        • Magann F.F.
        • Bass D.
        • Chauhan S.P.
        Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes and low platlets (HELLP).
        Am J Obstet Gynecol. 1994; 171: 1148-1153
        • Sullivan C.A.
        • Magann E.F.
        • Perry Jr, K.G.
        • et al.
        The recurrence risk of the syndrome of hemolysis, elevated liver enzymes, and low platlets (HELLP) in subsequent gestations.
        Am J Obstet Gynecol. 1994; 171: 940-943