To better comprehend the antibiotic recommendations in this article, the reader should
be cognizant of a number of clinical, microbiologic, pharmacologic, and epidemiologic
observations, as well as fundamental pharmacodynamic concepts. Taking into consideration
that empiric antimicrobial therapy in the critical care unit (CCU) is the norm rather
than the exception, the clinician must be familiar with the suspected pathogens from
infectious processes acquired both in the community and in the hospital. In fact,
most often the actual causative pathogen(s) of a given infection is rarely determined
with certainty. A fundamental understanding of pharmacodynamic concepts is essential;
it forms the very basis for the design of dosing strategies that maximize clinical
efficacy while minimizing toxicity.
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Article info
Footnotes
Address reprint requests to Paul G. Ambrose, PharmD, Research Administration, Hartford Hospital, 80 Seymour Street, P.O. Box 5037, Hartford, CT 06102–5037
Identification
Copyright
© 1998 W. B. Saunders Company. Published by Elsevier Inc. All rights reserved.
