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Review Article| Volume 26, ISSUE 2, P239-253, April 2010

Oxygen Delivery and Consumption: A Macrocirculatory Perspective

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      References

        • Angus D.C.
        • Linde-Zwirble W.T.
        • Lidicker J.
        • et al.
        Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.
        Crit Care Med. 2001; 29: 1303-1310
        • Dombrovskiy V.Y.
        • Martin A.A.
        • Sunderram J.
        • et al.
        Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.
        Crit Care Med. 2007; 35: 1244-1250
        • Waisbren B.A.
        Bacteremia due to gram-negative bacilli other than the Salmonella: a clinical and therapeutic study.
        Arch Intern Med. 1951; 88: 467-488
        • Cain S.M.
        • Curtis S.E.
        Experimental models of pathologic oxygen supply dependency.
        Crit Care Med. 1991; 19: 603-611
        • Edwards J.D.
        Oxygen transport in cardiogenic and septic shock.
        Crit Care Med. 1991; 19: 658-663
        • Krejci V.
        • Hiltebrand L.B.
        • Sigurdsson G.H.
        Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis.
        Crit Care Med. 2006; 34: 1456-1463
        • De Backer D.
        • Creteur J.
        • Dubois M.-J.
        The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects.
        Crit Care Med. 2006; 34: 403-408
        • Sair M.
        • Etherington P.J.
        • Winlove C.P.
        • et al.
        Tissue oxygenation and perfusion in patients with systemic sepsis.
        Crit Care Med. 2001; 29: 1343-1349
        • Massimo-Girardis M.
        • Rinaldi L.
        • Busani S.
        • et al.
        Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients.
        Intensive Care Med. 2003; 29: 1173-1176
        • Brealey D.
        • Brand M.
        • Hargreaves I.
        • et al.
        Association between mitochondrial dysfunction and severity and outcome of septic shock.
        Lancet. 2002; 360: 219-223
        • Fredriksson K.
        • Hammarqvist F.
        • Strigård K.
        • et al.
        Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure.
        Am J Physiol Endocrinol Metab. 2006; 291: E1044-E1050
        • Baudouin S.V.
        • Saunders D.
        • Tiangyou W.
        • et al.
        Mitochondrial DNA and survival after sepsis: a prospective study.
        Lancet. 2005; 366: 2118-2121
        • Crouser E.D.
        • Julian M.W.
        • Dorinsky P.M.
        Ileal VO2-DO2 alterations induced by endotoxin correlate with severity of mitochondrial injury.
        Am J Respir Crit Care Med. 1999; 160: 1347-1353
        • Watts J.A.
        • Kline J.A.
        • Thornton L.R.
        • et al.
        Metabolic dysfunction and depletion of mitochondria in hearts of septic rats.
        J Mol Cell Cardiol. 2004; 36: 141-150
        • Hotchkiss R.S.
        • Swanson P.E.
        • Freeman B.D.
        • et al.
        Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.
        Crit Care Med. 1999; 27: 1230-1251
        • Mongardon N.
        • Dyson A.
        • Singer M.
        Is MOF an outcome parameter or a transient, adaptive state in critical illness?.
        Curr Opin Crit Care. 2009; 15: 431-436
        • Leach R.M.
        • Treacher D.F.
        The pulmonary physician in critical care: oxygen delivery and consumption in the critically ill.
        Thorax. 2002; 57: 170-177
        • Dantzker D.
        • Foresman B.
        • Gutierrez G.
        Oxygen supply and utilization relationships.
        Am Rev Respir Dis. 1991; 143: 675-679
      1. Guzman JA. Monitoring oxygen transport. In: Kruse JA, Fink MP, Carlson RW, editors. Saunders manual of critical care. p. 781–3, chapter 216.

        • Mahutte C.K.
        • Jaffe M.B.
        • Sasse S.A.
        • et al.
        Relationship of thermodilution cardiac output to metabolic measurements and mixed venous oxygen saturation.
        Chest. 1993; 104: 1236-1242
        • Danek S.J.
        • Lynch J.P.
        • Weg J.G.
        • et al.
        The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome.
        Am Rev Respir Dis. 1980; 122: 387-395
        • Mohsenifar Z.
        • Goldbach P.
        • Tashkin D.P.
        • et al.
        Relationship between oxygen consumption and oxygen delivery in adult respiratory distress syndrome.
        Chest. 1983; 84: 267-271
        • Shoemaker W.C.
        • Chang P.C.
        • Czer L.S.C.
        • et al.
        Cardiorespiratory monitoring in postoperative patients: prediction of outcome and severity of illness.
        Crit Care Med. 1979; 7: 237-242
        • Phang P.T.
        • Cunningham K.F.
        • Ronco J.J.
        • et al.
        Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS.
        Am J Respir Crit Care Med. 1994; 150: 318-323
        • Squara P.
        Matching total body oxygen consumption and delivery: a crucial objective?.
        Intensive Care Med. 2004; 30: 2170-2179
        • De Backer D.
        VO2/DO2 relationship: how to get rid of the methodological pitfalls?.
        Intensive Care Med. 2000; 26: 1719-1722
        • Granton J.T.
        • Walley K.R.
        • Phang P.T.
        • et al.
        Assessment of three methods to reduce the influence of mathematical coupling on oxygen consumption and delivery relationships.
        Chest. 1998; 113: 1347-1355
        • Bihari D.
        • Smithies M.
        • Gimson A.
        • et al.
        The effect of vasodilation with prostacyclin on oxygen delivery and uptake in critically ill patients.
        N Engl J Med. 1987; 317: 397-403
        • Hayes M.A.
        • Yau E.H.
        • Timmins A.C.
        • et al.
        Response of critically ill patients to treatment aimed at achieving supranormal oxygen delivery and consumption: relationship to outcome.
        Chest. 1993; 103: 886-895
        • Rhodes A.
        • Lamb F.
        • Malago I.
        • et al.
        A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock.
        Crit Care Med. 1999; 27: 2361-2366
        • Vallet B.
        • Chopin C.
        • Curtis S.E.
        • et al.
        Prognostic value of the dobutamine test in patients with sepsis syndrome and normal lactate values: a prospective, multicenter study.
        Crit Care Med. 1993; 21: 1868-1875
        • Gladwin M.T.
        • Patel R.P.
        The role of red blood cells and hemoglobin–nitric oxide interactions on blood flow.
        Am J Respir Cell Mol Biol. 2008; 38: 125-126
        • Cain S.M.
        Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia.
        J Appl Phys. 1977; 42: 228-234
        • Gutierrez G.
        • Warley A.R.
        • Dantzker D.R.
        Oxygen delivery and utilization in hypothermic dogs.
        J Appl Phys. 1986; 63: 1487-1492
        • Nelson D.P.
        • Beyer C.
        • Samsel R.W.
        • et al.
        Pathological supply dependence of O2 uptake during bacteremia in dogs.
        J Appl Phys. 1987; 63: 1487-1492
        • Lieberman J.A.
        • Weiskopf R.B.
        • Kelley S.
        • et al.
        Critical oxygen delivery in conscious humans is less than 7.3 ml O2 kg−1.min−1.
        Anesthesiology. 2000; 92: 407-413
        • Weiskopf R.B.
        • Feiner J.
        • Hopf H.W.
        • et al.
        Oxygen reverses deficits of cognitive function and memory and increased heart rate induced by acute severe isovolemic anemia.
        Anesthesiology. 2002; 96: 871-877
        • Shibutani K.
        • Komatsu T.
        • Kubal K.
        • et al.
        Critical level of oxygen delivery in anesthetized man.
        Crit Care Med. 1983; 11: 640-643
        • Komatsu T.
        • Shibutani K.
        • Okamoto K.
        • et al.
        Critical level of oxygen delivery after cardiopulmonary bypass.
        Crit Care Med. 1987; 15: 194-197
        • Van Woerkens E.C.
        • Trouwborst A.
        • van Lanschot J.J.B.
        Profound hemodilution: what is the critical level of hemodilution at which oxygen delivery-dependent oxygen consumption starts in an anesthetized human?.
        Anesth Analg. 1992; 75: 818-821
        • Weg J.G.
        Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems: relationship of oxygen delivery and oxygen consumption.
        Crit Care Med. 1991; 19: 650-667
        • Shoemaker W.C.
        • Appel P.L.
        • Kram H.B.
        • et al.
        Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients.
        Chest. 1988; 94: 1176-1186
        • Ronco J.J.
        • Fenwick J.C.
        • Tweeddale M.G.
        • et al.
        Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans.
        JAMA. 1993; 270: 1724-1730
        • Kreymann G.
        • Grosser S.
        • Buggisch P.
        • et al.
        Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock.
        Crit Care Med. 1992; 21: 1012-1019
        • Shoemaker W.C.
        • Appel P.L.
        • Bland R.
        Use of physiologic monitoring to predict outcome and to assist in clinical decisions in critically ill postoperative patients.
        Am J Surg. 1983; 146: 43-50
        • Tuchschmidt J.
        • Fried J.
        • Astiz M.
        • et al.
        Elevation of cardiac output and oxygen delivery improves outcome in septic shock.
        Chest. 1992; 102: 216-220
        • Hayes M.A.
        • Timmins A.C.
        • Yau E.H.
        Oxygen transport patterns in patients with sepsis syndrome or septic shock: influence of treatment and relationship to outcome.
        Crit Care Med. 1997; 25: 926-936
        • Yu M.
        • Levy M.
        • Smith P.
        • et al.
        Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: a prospective, randomized, controlled study.
        Crit Care Med. 1993; 21: 830-838
        • Gattinoni L.
        • Brazzi L.
        • Pelosi P.
        • et al.
        A trial of goal-oriented hemodynamic therapy in critically ill patients.
        N Engl J Med. 1995; 333: 1025-1032
        • Vinay K.
        • Sharma V.K.
        • Dellinger R.P.
        The International Sepsis Forum's Frontiers in Sepsis: high cardiac output should not be maintained in severe sepsis.
        Crit Care. 2003; 7: 272-275
        • Kumar A.
        • Schupp E.
        • Bunnell E.
        • et al.
        Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock.
        Crit Care. 2008; 12: R35
        • Parker M.M.
        • Shelhamer J.H.
        • Natanson C.
        • et al.
        Serial cardiovascular variables in survivors and non-survivors of human septic shock: heart rate as an early indicator of prognosis.
        Crit Care Med. 1987; 10: 923-929
        • Ognibene F.P.
        • Parker M.M.
        • Natanson C.
        • et al.
        Depressed left ventricular performance: response to volume infusion in patients with sepsis and septic shock.
        Chest. 1988; 93: 903-910
        • Parker M.M.
        • Ognibene F.P.
        • Parrillo J.E.
        Peak systolic pressure/end-systolic volume ratio, a load-independent measure of ventricular function, is reversibly decreased in human septic shock.
        Crit Care Med. 1994; 22: 1955-1959
        • Lundberg J.S.
        • Perl T.M.
        • Wiblin T.
        • et al.
        Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units.
        Crit Care Med. 1998; 26: 1020-1024
        • Nguyen H.B.
        • Rivers E.P.
        • Haystad S.
        • et al.
        Critical care in the emergency department: a physiologic assessment and outcome evaluation.
        Acad Emerg Med. 2000; 7: 1354-1361
        • Rivers E.
        • Nguyen B.
        • Haystad S.
        • et al.
        Early goal-directed therapy in the treatment of severe sepsis and septic shock.
        N Engl J Med. 2001; 345: 1368-1377
        • Donnino M.W.
        • Nguyen B.
        • Jacobsen G.
        • et al.
        Cryptic septic shock: a sub-analysis of early, goal-directed therapy.
        Chest. 2003; 124: 90S
        • Burton T.
        The Wall Street Journal.
        (Available at:) (Accessed August 14, 2008)
        • Dellinger R.P.
        • Levy M.M.
        • Carlet J.M.
        • et al.
        Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock.
        Intensive Care Med. 2008; 34: 17-60
        • Clinical Trials Gov
        (Available at:) (Accessed December 1, 2009)
        • Hebert P.C.
        • Wells G.
        • Blajchman M.A.
        • et al.
        A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
        N Engl J Med. 1999; 340: 409-417