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References
- Post-injury multiple organ failure: the role of the gut.Shock. 2001; 15: 1-10
- Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined.Crit Care Med. 2003; 31: 598-607
- Intestinal epithelial hyperpermeability: update on the pathogenesis of gut mucosal barrier dysfunction in critical illness.Curr Opin Crit Care. 2003; 9: 143-151
- Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice.Shock. 2004; 21: 261-270
- Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level.Crit Care Clin. 2005; 21: 177-196
- Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review.Front Biosci. 2006; 11: 520-528
- Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis.JAMA. 2002; 287: 1716-1721
- Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice.Crit Care Med. 2002; 30: 195-201
- Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types.Am J Anat. 1974; 141: 537-561
- Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis.J Cell Sci. 1994; 107: 3569-3577
- Tight junctions and cell-cell interactions.Methods Mol Biol. 2006; 341: 185-195
- Applications of imaging techniques to studies of epithelial tight junctions.Adv Drug Deliv Rev. 2005; 57: 111-121
- Mucosal repair in the gastrointestinal tract.Crit Care Med. 2003; 31 ([miscellaneous]): S532-S537
- Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells.J Clin Invest. 1992; 89: 1501-1511
- Rapid barrier restitution in an in vitro model of intestinal epithelial injury.Lab Invest. 1989; 60: 237-244
- Mechanisms and modulation of intestinal epithelial repair.Inflamm Bowel Dis. 2001; 7: 68-77
- Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils.Blood. 2002; 99: 2997-3004
- Human plasma epidermal growth factor/beta-urogastrone is associated with blood platelets.J Clin Invest. 1983; 72: 249-259
- Human platelet-derived mitogens. I. Identification of insulinlike growth factors I and II by purification and N alpha amino acid sequence analysis.Blood. 1989; 74: 1084-1092
- Purification and subunit structure of hepatocyte growth factor from rat platelets.FEBS Lett. 1987; 224: 311-316
- Why is epidermal growth factor present in the gut lumen?.Gut. 1996; 38: 303-305
- Gastrointestinal mucosal regeneration: role of growth factors.Front Biosci. 1999; 4: D303-D309
- Growth of intestinal epithelium in organ culture is dependent on EGF signalling.Exp Cell Res. 2005; 303: 252-262
- Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.Nature. 1995; 376: 337-341
- Effect of epidermal growth factor, transforming growth factor alpha and nerve growth factor on gastric mucosal integrity and microcirculation in the rat.Regul Pept. 1994; 50: 13-21
- Epidermal growth factor receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice.Gastroenterology. 2006; 130: 412-423
- Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis.Am J Physiol Gastrointest Liver Physiol. 2005; 288: G755-G762
- Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor.J Pediatr Gastroenterol Nutr. 2003; 36: 126-133
- Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment.Am J Physiol Gastrointest Liver Physiol. 2006; 291: G938-G949
- Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis.Am J Physiol Gastrointest Liver Physiol. 2009; 297: G471-G479
- Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.Shock. 2008; 30: 36-42
- Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage.Am J Pathol. 2002; 161: 373-379
- Epidermal growth factor protects gastric mucosa against ischemia-reperfusion injury.J Clin Gastroenterol. 1993; 17: S104-S110
- Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents.Burns. 2002; 28: 435-442
- Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model.Am J Physiol Gastrointest Liver Physiol. 2002; 282: G156-G164
- Intestinal overexpression of EGF in transgenic mice enhances adaptation after small bowel resection.Am J Physiol. 1999; 277: G533-G540
- Epidermal growth factor enhances intestinal adaptation after massive small bowel resection.J Pediatr Surg. 1994; 29: 1035-1038
- A defective EGF-receptor in waved-2 mice attenuates intestinal adaptation.J Surg Res. 1997; 69: 76-80
- Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats.Gastroenterology. 1992; 102: 695-698
- Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study.J Gastroenterol Hepatol. 1994; 9: S78-S83
Clinical trials. Other. 10-19-0009. 10-13-0009. Ref Type: Electronic Citation. Available at: http://clinicaltrials.gov/ct2/results?term=epidermal+growth+factor. Accessed October 13, 2009.
- Epidermal growth factor enemas with oral mesalamine for mild-to-moderate left-sided ulcerative colitis or proctitis.N Engl J Med. 2003; 349: 350-357
- Intestinal mucosa remodeling by recombinant human epidermal growth factor(1-48) in neonates with severe necrotizing enterocolitis.J Pediatr Surg. 2007; 42: 462-469
- Treatment with GH and IGF-1 in critical illness.Crit Care Clin. 2006; 22 (vi): 29-40
- Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection [miscellaneous article].Curr Opin Clin Nutr Metab Care. 2002; 5: 271-279
- Growth hormone, burns and tissue healing.Growth Horm IGF Res. 2000; 10: S39-S43
- IGF-I/IGFBPs system response to endotoxin challenge in sheep.J Endocrinol. 2000; 164: 361-369
- Systemic and splanchnic metabolic response to exogenous human growth hormone.Surgery. 1998; 123: 528-538
- Expression of the growth hormone receptor gene in human digestive tissue.J Clin Endocrinol Metab. 1994; 78: 1473-1480
- Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.Gastroenterology. 1993; 104: 973-980
- Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone.Gastroenterology. 2001; 120: 925-937
- Effects of growth hormone (rhGH) and glutamine supplemented parenteral nutrition on intestinal adaptation in short bowel rats.Clin Nutr. 2001; 20: 159-166
- Small bowel adaptation with growth hormone and glutamine after massive resection of rat's small bowel.Nutr Hosp. 1999; 14: 81-90
- Enterotrophic effect of insulin-like growth factor-I but not growth hormone and localized expression of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and -5 mRNAs in jejunum of parenterally fed rats.JPEN J Parenter Enteral Nutr. 2000; 24: 288-295
- GH elevates serum IGF-I levels but does not alter mucosal atrophy in parenterally fed rats.Am J Physiol. 1997; 272: G1100-G1108
- The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma.J Surg Res. 2005; 127: 183-189
- Growth factors in critical illness: regulation and therapeutic aspects.Curr Opin Clin Nutr Metab Care. 1998; 1 ([miscellaneous article]): 195-204
- Role of insulin-like growth factors in embryonic and postnatal growth.Cell. 1993; 75: 73-82
- Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.J Biol Chem. 2004; 279: 38016-38024
- Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I.Gastroenterology. 1997; 112: 444-454
- Insulin-like growth factor-I improves mucosal structure and function in transplanted rat small intestine.Transplantation. 1995; 59: 755-761
- Insulinlike growth factor 1 (IGF-1) reduces gut atrophy and bacterial translocation after severe burn injury.Arch Surg. 1993; 128: 47-53
- Prophylactic treatment with growth hormone and insulin-like growth factor I improve systemic bacterial clearance and survival in a murine model of burn-induced gut-derived sepsis.Burns. 1999; 25: 425-430
- Insulin-like growth factor attenuates apoptosis and mucosal damage in hypoxia/reoxygenation-induced intestinal injury.Biol Neonate. 2005; 87: 91-96
- IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis.J Surg Res. 2006; 136: 31-37
- Increased mortality associated with growth hormone treatment in critically ill adults.N Engl J Med. 1999; 341: 785-792
- Is there a role for growth hormone therapy in refractory critical illness?.Curr Opin Crit Care. 2008; 14: 438-444
- Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children.Ann Surg. 2009; ([Epub ahead of print]. PMID: 19734776)
- Adverse effects of recombinant human insulin-like growth factor I in obese insulin-resistant type II diabetic patients.Diabetes. 1994; 43: 369-374
- Clinical uses of insulin-like growth factor I.Ann Intern Med. 1994; 120: 593-601
- Anabolic effects of insulin-like growth factor in combination with insulin-like growth factor binding protein-3 in severely burned adults.J Trauma. 1999; 47: 904-910
- Muscle protein catabolism after severe burn: effects of IGF-1/IGFBP-3 treatment.Ann Surg. 1999; 229: 713-720
- IGF-I/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients.Mol Med. 2002; 8: 238-246
- Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children.Ann Surg. 2000; 231: 246-252
- Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3.Endocrinology. 2007; 148: 354-362
- Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth.Science. 1989; 245: 752-755
- Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.Am J Pathol. 1996; 149: 521-529
- Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.J Clin Invest. 1994; 94: 1764-1777
- Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats.Gastroenterology. 1996; 110: 1077-1083
- Protection of the intestinal mucosa by intraepithelial gamma delta T cells.Proc Natl Acad Sci U S A. 2002; 99: 14338-14343
- Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via Bcl-2.J Pediatr Surg. 2003; 38: 92-96
- Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair.Adv Cancer Res. 2004; 91: 69-136
- Enhancement of murine intestinal stem cell survival after irradiation by keratinocyte growth factor.Radiat Res. 1997; 148: 248-253
- Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality.Cancer Res. 1998; 58: 933-939
- Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind, placebo-controlled, dose-escalation trial.Aliment Pharmacol Ther. 2003; 17: 1355-1364
- Hepatocyte growth factor promotes colonic epithelial regeneration via Akt signaling.Am J Physiol Gastrointest Liver Physiol. 2007; 293: G230-G239
- Mucosal repair and growth factors: recombinant human hepatocyte growth factor as an innovative therapy for inflammatory bowel disease.J Gastroenterol. 2005; 40: 925-931
- Hepatocyte growth factor accelerates restitution of intestinal epithelial cells.J Gastroenterol. 1998; 33: 172-178
- Growth-factor enhancement of compromised gut function following massive small-bowel resection.Pediatr Surg Int. 2000; 16: 174-175
- The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma.Surgery. 2005; 138: 482-489
- Hepatocyte growth factor pretreatment reduces apoptosis and mucosal damage after intestinal ischemia-reperfusion.J Pediatr Surg. 2002; 37: 1093-1097
- Hepatocyte growth factor facilitates colonic mucosal repair in experimental ulcerative colitis in rats.J Pharmacol Exp Ther. 2003; 307: 146-151
- Hepatocyte growth factor facilitates the repair of large colonic ulcers in 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats.Inflamm Bowel Dis. 2005; 11: 551-558
- Effects of hepatocyte growth factor on rat inflammatory bowel disease models.Dig Dis Sci. 2005; 50: 914-921
- Therapeutic effect of adenoviral-mediated hepatocyte growth factor gene administration on TNBS-induced colitis in mice.Biochem Biophys Res Commun. 2005; 329: 1217-1224
- Naked gene therapy of hepatocyte growth factor for dextran sulfate sodium-induced colitis in mice.Biochem Biophys Res Commun. 2006; 345: 1517-1525
- Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver.J Gene Med. 2006; 8: 623-635
- Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model.Am J Physiol Gastrointest Liver Physiol. 2005; 288: G729-G735
- Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers.Cell Growth Differ. 1996; 7: 1513-1523
- A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.Science. 1991; 251: 936-939
- Structure and function of heparin-binding EGF-like growth factor (HB-EGF).Front Biosci. 1998; 3: d288-d299
- Endogenous production of heparin-binding EGF-like growth factor during murine partial-thickness burn wound healing.J Burn Care Rehabil. 2002; 23: 116-125
- Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro.J Pediatr Surg. 2001; 36: 1130-1135
- Heparin-binding EGF-like growth factor is cytoprotective for intestinal epithelial cells exposed to hypoxia.J Pediatr Surg. 1998; 33: 973-978
- Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo.Antioxid Redox Signal. 2002; 4: 639-646
- Heparin-binding EGF-like growth factor preserves crypt cell proliferation and decreases bacterial translocation after intestinal ischemia/reperfusion injury.J Pediatr Surg. 2002; 37: 1081-1087
- Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis.J Pediatr Surg. 2007; 42: 214-220
- Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitation.Surgery. 2007; 142: 234-242
- Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system.Endocrinology. 2004; 145: 2653-2659
- GLP-2 augments the adaptive response to massive intestinal resection in rat.Am J Physiol. 1998; 275: G911-G921
- Hormonal therapy for short bowel syndrome.J Pediatr Surg. 2000; 35: 360-363
- Treatment of inflammatory bowel disease in a rodent model with the intestinal growth factor glucagon-like peptide-2.J Pediatr Surg. 2000; 35: 847-851
- Glucagon-like peptide-2 and common therapeutics in a murine model of ulcerative colitis.J Pharmacol Exp Ther. 2003; 306: 347-354
- Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis.Am J Physiol. 1999; 277: E937-E947
- Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy.Am J Physiol Gastrointest Liver Physiol. 2003; 284: G905-G912
- Glucagon-like peptide-2 enhances intestinal epithelial barrier function of both transcellular and paracellular pathways in the mouse.Gut. 2000; 47: 112-119
- The effect of glucagon-like peptide 2 on intestinal permeability and bacterial translocation in acute necrotizing pancreatitis.Am J Surg. 2001; 181: 571-575
- Glucagon-like peptide-2 stimulates gut mucosal growth and immune response in burned rats.J Burn Care Rehabil. 2001; 22: 136-143
- Glucagonlike peptide-2 analogue enhances intestinal mucosal mass and absorptive function after ischemia-reperfusion injury.J Pediatr Surg. 2000; 35: 1537-1539
- Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis.Am J Physiol. 1999; 276: G79-G91
- GLP-2 stimulates intestinal growth in premature TPN-fed pigs by suppressing proteolysis and apoptosis.Am J Physiol Gastrointest Liver Physiol. 2000; 279: G1249-G1256
- GLP-2 rapidly activates divergent intracellular signaling pathways involved in intestinal cell survival and proliferation in neonatal piglets.Am J Physiol Endocrinol Metab. 2007; 292: E281-E291
- Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon.Gastroenterology. 2001; 120: 806-815
- Trefoil peptides: a new family of gastrointestinal molecules.Digestion. 1994; 55: 353-360
- Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats.Gastroenterology. 1996; 110: 489-497
- Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats.J Gastroenterol Hepatol. 1998; 13: 363-370
- Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis.Gut. 1999; 44: 636-642
- Intestinal trefoil factor confers colonic epithelial resistance to apoptosis.Proc Natl Acad Sci U S A. 2000; 97: 799-804
- The trefoil peptide family.Annu Rev Physiol. 1996; 58: 253-273
- Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor.Science. 1996; 274: 262-265
- Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model.J Perinat Med. 2007; 35: 443-446
- Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice.Gastroenterology. 2004; 127: 502-513
- Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.Gastroenterology. 2004; 126: 796-808
- Intestinal trefoil factor produced in Escherichia coli promotes the healing of rat burn-induced acute gastric mucosal lesions.J Trauma. 2008; 65 ([article]): 163-169
- Stability analysis of recombinant human TFF2 and its therapeutic effect on burn-induced gastric injury in mice.Burns. 2009; 35: 869-874
- Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure.Clin Sci (Lond). 2006; 110: 563-573
- Combined effects of glutamine and epidermal growth factor on the rat intestine.Surgery. 1988; 104: 358-364
- Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation.Surgery. 1993; 114: 147-153
- Insulin-like growth factor-I (IGF-I) and glutamine improve structure and function in the small bowel allograft.J Surg Res. 1995; 59: 6-12
- Growth hormone, glutamine, and a modified diet enhance nutrient absorption in patients with severe short bowel syndrome.JPEN J Parenter Enteral Nutr. 1995; 19: 296-302
Article info
Footnotes
This work was supported by from the National Institutes of Health (GM66202, GM072808, and F32 GM082008) and the Shock Society Research Fellowship for Early Career Investigators.
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