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References
- The epidemiology of sepsis in the United States from 1979 through 2000.N Engl J Med. 2003; 348: 1546-1554
- Deaths: final data for 1998.Natl Vital Stat Rep. 2000; 48: 1-105
- Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.Crit Care Med. 2007; 35: 1244-1250
- The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study.JAMA. 1995; 273: 117-123
- Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?.Crit Care Clin. 2002; 18: 165-175
- A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy-rich phosphates, protein, nucleic acids, fat, water, and electrolytes.Crit Care Med. 1996; 24: 575-583
- Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance.Q J Exp Physiol. 1985; 70: 473-489
- The effect of glutamine supplementation in patients following elective surgery and accidental injury.J Nutr. 2001; 131 ([discussion: 2550S–1S]): 2543S-2549S
- Plasma glutamine depletion and patient outcome in acute ICU admissions.Intensive Care Med. 2001; 27: 84-90
- Glutamine: role in critical illness and ongoing clinical trials.Curr Opin Gastroenterol. 2008; 24: 190-197
- The role of glutamine in intensive care unit patients: mechanisms of action and clinical outcome.Nutr Rev. 2005; 63: 65-69
- Glutamine, a life-saving nutrient, but why?.Crit Care Med. 2003; 31: 2555-2556
- Glutamine, gene expression, and cell function.Front Biosci. 2007; 12: 344-357
- Glutamine and heat shock protein expression.Nutrition. 2002; 18: 225-228
- Glutamine's protection against cellular injury is dependent on heat shock factor-1.Am J Phys Cell Physiol. 2006; 290: C1625-C1632
- Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression?.Curr Opin Clin Nutr Metab Care. 2006; 9: 201-206
- Speculations on the functions of the major heat shock and glucose-regulated proteins.Cell. 1986; 46: 959-961
- Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness.Curr Opin Anaesthesiol. 2009; 22: 177-183
- Cecal ligation and double puncture impairs heat shock protein 70 (HSP-70) expression in the lungs of rats.Shock. 2000; 13: 19-23
- Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression.Crit Care Med. 2005; 33: 1206-1213
- Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.JPEN J Parenter Enteral Nutr. 2008; 32: 371-376
- Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity.Am J Physiol Cell Physiol. 2009; 297: C1509-C1519
- Cell signaling, the essential role of O-GlcNAc!.Biochim Biophys Acta. 2006; 1761: 599-617
- Glutamine protects intestinal epithelial cells: role of inducible HSP70.Am J Physiol. 1997; 272: G879-G884
- Parenteral glutamine increases serum heat shock protein 70 in critically ill patients.Intensive Care Med. 2005; 31: 1079-1086
- Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model.Shock. 1994; 2 ([discussion: 40]): 34-39
- Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury.Am Rev Respir Dis. 1993; 147: 177-181
- Heat stress increases survival rates in lipopolysaccharide-stimulated rats.Crit Care Med. 1997; 25: 1727-1732
- Glutamine prevents activation of nf-kappab and stress kinase pathways, attenuates inflammatory cytokine release, and prevents acute respiratory distress syndrome (ARDS) following sepsis.Shock. 2005; 24: 583-589
- Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1–TLR4 signaling.J Immunol. 2007; 178: 6573-6580
- Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway.Am J Physiol Gastrointest Liver Physiol. 2005; 289: G388-G396
- Rapid induction of the intrinsic apoptotic pathway by L-glutamine starvation.J Cell Physiol. 2005; 202: 912-921
- Molecular mechanisms contributing to glutamine-mediated intestinal cell survival.Am J Physiol Gastrointest Liver Physiol. 2007; 293: G1262-G1271
- Nonnutritive effects of glutamine.J Nutr. 2008; 138: 2025S-2031S
- L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study.Crit Care Med. 2006; 34: 598-604
- Parenterally administered dipeptide alanyl-glutamine prevents worsening of insulin sensitivity in multiple-trauma patients.Crit Care Med. 2006; 34: 381-386
- Glutamine supplementation in serious illness: a systematic review of the evidence.Crit Care Med. 2002; 30: 2022-2029
- Effect of dipeptide of glutamine and alanine on severe traumatic brain injury.Clin J Traumatool. 2007; 10: 145-149
- Intravenous glutamine supplementation to head trauma patients leaves cerebral glutamate concentration unaffected.Intensive Care Med. 2006; 32: 1741-1746
- The pattern of amino acid exchange across the brain is unaffected by intravenous glutamine supplementation in head trauma patients.Clin Nutr. 2008; 27: 816-821
- Optimizing the dose of glutamine dipeptides and anitoxidants in critically ill patients: a phase I dose-finding study.JPEN J Parenter Enteral Nutr. 2007; 31: 109-118
- Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.JPEN J Parenter Enteral Nutr. 2009; 33: 277-316
- ESPEN guidelines on parenteral nutrition: intensive care.Clin Nutr. 2009; 28: 387-400
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Footnotes
This work supported by National Institutes of Health Grants NCRR-K23 RR018379, NIDDK-RO3 DK073035, NIDDK-U01 DK069322, and NIGMS-RO1 GM078312—all to Paul E. Wischmeyer, MD.
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© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.