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Review Article| Volume 26, ISSUE 3, P567-575, July 2010

Mitochondrial Dysfunction and Resuscitation in Sepsis

  • Albert J. Ruggieri
    Affiliations
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA

    The Stavropoulos Sepsis Research Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
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  • Richard J. Levy
    Affiliations
    Division of Anesthesiology and Pain Medicine, Children's National Medical Center, Washington, DC 20010, USA

    The Stavropoulos Sepsis Research Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
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  • Clifford S. Deutschman
    Correspondence
    Corresponding author. Dulles 781A/HUP, 3400 Spruce Street, Philadelphia, PA 19104-4283.
    Affiliations
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA

    The Stavropoulos Sepsis Research Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA
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      References

        • Angus D.C.
        • Linde-Zwirble W.T.
        • Lidicker J.
        • et al.
        Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.
        Crit Care Med. 2001; 29: 1303-1310
        • Members of the American College of Chest Physicians/Society of Critical Care Consensus Committee; American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference
        Definitions of sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.
        Crit Care Med. 1992; 20: 864-874
        • Levy M.M.
        • Fink M.P.
        • Marshall J.C.
        • et al.
        2001 SCCM/ESICM/ACCP/ATS/SIS International sepsis definition conference.
        Crit Care Med. 2003; 31: 1250-1256
        • Barcroft H.
        • Allen W.J.
        • Anderson D.P.
        • et al.
        Circulatory changes during fainting and coma caused by oxygen lack.
        J Physiol. 1946; 104: 426-434
        • Hotchkiss R.S.
        • Karl I.E.
        Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis.
        JAMA. 1992; 267: 1503-1510
        • Brealey D.
        • Karyampudi S.
        • Jacques T.S.
        • et al.
        Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.
        Am J Phys. 2004; 286: R491-R497
        • Fink M.P.
        Cytopathic hypoxia: mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis.
        Crit Care Clin. 2001; 17: 219-237
        • López L.C.
        • Escames G.
        • Ortiz F.
        • et al.
        Melatonin restores the mitochondrial production of ATP in septic mice.
        Neuro Endocrinol Lett. 2006; 27: 623-630
        • Weil M.H.
        • Shubin H.
        Proposed reclassification of shock states with special reference to distributive effects.
        Advance Experiments in Medical Biology. 1971; 23: 13-23
        • Elbers P.W.
        • Ince C.
        Bench-to-bedside review: mechanisms of critical illness—classifying microcirculatory flow abnormalities in distributive shock.
        Crit Care Clin. 2006; 10: 221
        • Fink M.P.
        Bench-to-bedside review: cytopathic hypoxia.
        Crit Care Clin. 2002; 6: 491-499
        • Fink M.P.
        Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of acquired intrinsic derangement in cellular respiration?.
        Crit Care Clin. 2002; 18: 165-175
        • Vary T.C.
        • Siegel J.H.
        • Nakatani T.
        • et al.
        Effect on sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver.
        Am J Physiol Endocrinol Metab. 1986; 250: E634-E640
        • Vary T.C.
        • Hazen S.
        Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle.
        Mol Cell Biochem. 1999; 198: 113-118
        • Kantrow S.P.
        • Taylor D.E.
        • Carraway M.S.
        • et al.
        Oxidative metabolism in rat hepatocytes and mitochondria during sepsis.
        Arch Biochem Biophys. 1997; 345: 278-288
        • Kantrow S.P.
        • Tatro L.G.
        • Piantidosi C.A.
        Oxidative stress and adenine nucleotide control of mitochondrial permeability transition.
        Free Radic Biol Med. 2000; 28: 251-260
        • Levy R.J.
        Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis.
        Shock. 2007; 28: 24-28
        • Levy R.J.
        • Vijayasarathy C.
        • Raj N.R.
        • et al.
        Competitive and noncompetitive inhibition of myocardial cytochrome c oxidase in sepsis.
        Shock. 2004; 21: 110-114
        • Fredriksson K.
        • Hammarqvist F.
        • Strigard K.
        • et al.
        Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure.
        Am J Phys. 2006; 291: E1044-E1050
        • Brealey D.
        • Brand M.
        • Hargreaves L.
        • et al.
        Association between mitochondrial dysfunction and severity and outcome of septic shock.
        Lancet. 2002; 360: 219-223
        • Clementi E.
        • Brown G.C.
        • Feelisch M.
        • et al.
        Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.
        Proc Natl Acad Sci U S A. 1998; 95: 7631-7636
        • Bolanos J.P.
        • Heales S.J.
        • Peuchen S.
        • et al.
        Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione.
        Free Radic Biol Med. 1996; 21: 995-1001
        • Hoffman D.L.
        • Brookes P.S.
        Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions.
        J Biol Chem. 2009; 284: 16236-16245
        • Taylor D.E.
        • Ghio A.J.
        • Piantadosi C.A.
        Reactive oxygen species produced by liver mitochondria of rats in sepsis.
        Arch Biochem Biophys. 1995; 316: 70-76
        • Rada B.
        • Leto T.L.
        Oxidative innate immune defenses by Nox/Duox family NADPH oxidases.
        Contrib Microbiol. 2008; 15: 164-187
        • Piel D.A.
        • Gruber P.J.
        • Weinheimer C.J.
        • et al.
        Mitochondrial resuscitation with exogenous cytochrome c in the septic heart.
        Crit Care Med. 2007; 35: 2120-2127
        • Piel D.A.
        • Deutschman C.S.
        • Levy R.J.
        Exogenous cytochrome c restores myocardial cytochrome oxidase activity into the late phase of sepsis.
        Shock. 2008; 29: 612-616
        • Verma R.
        • Huang Z.
        • Deutschman C.S.
        • et al.
        Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis.
        Crit Care Med. 2009; 37: 1397-1402
        • Zivadinovic D.
        • Marjanovic M.
        • Andjus R.K.
        Some components of hibernation rhythms.
        Ann N Y Acad Sci. 2005; 1048: 60-68
        • Blackstone E.
        • Morrison M.
        • Roth M.B.
        H2S induces a suspended animation-like state in mice.
        Science. 2005; 308: 518
        • Burwell L.S.
        • Nadtochiy S.M.
        • Brookes P.S.
        Cardioprotection by metabolic shut-down and gradual wake-up.
        J Mol Cell Cardiol. 2009; 46: 804-810
        • Pelicano H.
        • Martin D.S.
        • Xu R.H.
        • et al.
        Glycolysis inhibition for anticancer treatment.
        Oncogene. 2006; 25: 4633-4646
        • Bender D.A.
        • Mayes P.A.
        Glycolysis and the oxidation of pyruvate; Harper's illustrated biochemistry.
        28th edition. The McGraw-Hill Companies, 2009
        • Protti A.
        • Singer M.
        Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure.
        Crit Care Forum. 2006; 10: 228