Advertisement
Review Article| Volume 26, ISSUE 4, P637-640, October 2010

Venous Thromboembolic Disease and Hematologic Considerations in Obesity

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Critical Care Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Geerts W.
        • Bergqvist D.
        • Pineo G.
        • et al.
        Prevention of venous thromboembolism the seventh ACCP Conference on antithrombotic and thrombolytic therapy.
        Chest. 2006; 126: 338S-400S
        • Hirsch D.R.
        • Ingenito E.P.
        • Goldhaber S.Z.
        Prevalence of deep venous thrombosis among patients in medical intensive care.
        JAMA. 1995; 274: 335-337
        • Marik P.E.
        • Andrews L.
        • Maini B.
        The incidence of deep venous thrombosis in ICU patients.
        Chest. 1997; 111: 661-664
        • Stein P.
        • Henry J.
        Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy.
        Chest. 1995; 108: 978-981
        • Moser K.M.
        • LeMoine J.R.
        • Nachtwey F.J.
        • et al.
        Deep venous thrombosis and pulmonary embolism: frequency in a respiratory intensive care unit.
        JAMA. 1981; 246: 1422-1424
        • Neuhaus A.
        • Bentz R.R.
        • Weg J.G.
        Pulmonary embolism in respiratory failure.
        Chest. 1978; 73: 460-465
        • Borch K.
        • Braekkan S.
        • Mathiesen E.
        • et al.
        Anthropometric measures of obesity and risk of venous thromboembolism.
        Arterioscler Thromb Vasc Biol. 2010; 30: 121-127
        • Stein P.
        • Beemath A.
        • Olson R.
        Obesity as a risk factor in venous thromboembolism.
        Am J Med. 2005; 118: 978-980
        • Goldhaber S.
        • Grodstein F.
        • Stampfer M.
        • et al.
        A prospective study of risk factors for pulmonary embolism in women.
        JAMA. 1997; 277: 642-645
        • Hansson P.
        • Welin L.
        • Tibblin G.
        • et al.
        Deep vein thrombosis and pulmonary embolism in the general population “The study of Men born in 1913”.
        Arch Intern Med. 1997; 157: 1665-1670
        • Eichenger S.
        • Hron G.
        • Bialonczyk C.
        • et al.
        Overweight, obesity and the risk of recurrent venous thromboembolism.
        Arch Intern Med. 2008; 168: 1678-1683
        • Barba R.
        • Zapatero A.
        • Losa J.E.
        • et al.
        Body mass index and mortality in patients with acute venous thromboembolism: findings from the RIETE registry.
        J Thromb Haemost. 2008; 6: 595-600
        • Geerts W.
        • Code K.
        • Jay R.
        • et al.
        A prospective study of venous thromboembolism after major trauma.
        N Engl J Med. 1994; 331: 1601-1606
        • Sartori M.T.
        • Danesin C.
        • Saggiorato G.
        • et al.
        The PAI-1 gene 4 G/5 G polymorphism and deep vein thrombosis in patients with inherited thrombophilia.
        Clin Appl Thromb Hemost. 2003; 9: 299-307
        • Loskutoff D.
        • Samad F.
        The adipocyte and hemostatic balance in obesity studies of PAI-1.
        Arterioscler Thromb Vasc Biol. 1998; 18: 1-6
        • Levi M.
        • Biemond B.J.
        • van Zonneveld A.J.
        • et al.
        Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.
        Circulation. 1992; 85: 305-312
        • Alessi M.
        • Vague I.
        PAI-1 and the metabolic syndrome links, causes and consequence.
        Arterioscler Thromb Vasc Biol. 2006; 26: 2200-2207
        • Kato H.
        • Kashiwagi H.
        • Shiraga M.
        • et al.
        Adiponectin acts as an endogenous antithrombotic factor.
        Arterioscler Thromb Vasc Biol. 2006; 26: 224-230
        • Basili S.
        • Pacini G.
        • Guagnano M.T.
        • et al.
        Insulin resistance as a determinant of platelet activation in obese women.
        J Am Coll Cardiol. 2006; 48: 2531-2538
        • Mertens I.
        • Van Gaal L.F.
        Obesity, haemostasis and the fibrinolytic system.
        Obes Rev. 2002; 3: 85-101
        • Warlow C.
        • McNeill A.
        • Ogston D.
        • et al.
        Platelet adhesiveness, coagulation and fibrinolytic activity in obesity.
        J Clin Pathol. 1972; 25: 484-486
        • Carmeliet P.
        • Schoonjans L.
        • Kieckens L.
        • et al.
        Physiological consequences of loss of plasminogen activator gene function in mice.
        Nature. 1994; 368: 419-424
        • Van Guilder G.
        • Hoetzer G.
        • Smith D.
        • et al.
        Endothelial t-PA release is impaired in overweight and obese adults but can be improved with regular aerobic exercise.
        Am J Physiol Endocrinol Metab. 2005; 289: 807-813
        • Overby D.W.
        • Kohn G.P.
        • Cahan M.A.
        • et al.
        Prevalence of thrombophilias in patients presenting for bariatric surgery.
        Obes Surg. 2009; 19: 1278-1285