Research Article| Volume 7, ISSUE 3, P521-532, July 1991

Anticonvulsant Agents

  • Fritz E. Dreifuss
    Address reprint requests to: Fritz E. Dreifuss, MD, FRCP, FRACP, Department of Neurology, School of Medicine, University of Virginia, Center for Health Sciences, Box 394, Charlottesville, VA 22908
    Professor, Department of Neurology, the University of Virginia, School of Medicine, Health Sciences Center, Charlottesviile, Virginia
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      Anticonvulsant agents are often placed into two groups: those that complicate drug administration in a relatively predictable manner and those that cause idiosyncratic reactions that are relatively unpredictable, unheralded, and frequently quite severe. This article examines the toxic effects of anticonvulsant drugs used to treat diseases commonly seen in the intensive care unit (ICU), where the situation is complicated by the severity of the primary pathologic condition, which frequently involves the use of drugs that may have a significant effect on the blood levels and efficacy of the anticonvulsant drugs. Complications associated with the route of drug administration and their signs and symptoms are also discussed.
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