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Research Article| Volume 7, ISSUE 3, P555-581, July 1991

Nitroprusside, Nitroglycerin, and Angiotensin-Converting Enzyme Inhibitors

  • Author Footnotes
    * Director, Medical Toxicology Fellowship, Departments of Medical Toxicology, Pharmacy, and Medicine
    Steven C. Curry
    Correspondence
    Address reprint requests to: Steven C. Curry, MD, Departments of Medical Toxicology, Pharmacy, and Medicine, Good Samaritan Regional Medical Center, Phoenix Children’s Hospital, 1111 E. McDowell Road, Phoenix, AZ 85006
    Footnotes
    * Director, Medical Toxicology Fellowship, Departments of Medical Toxicology, Pharmacy, and Medicine
    Affiliations
    From the Good Samaritan Regional Medical Center, Phoenix Children’s Hospital, Phoenix, Arizona
    Search for articles by this author
  • Author Footnotes
    † Associate Director, Department of Clinical Pharmacology
    Patricia Arnold-Capell
    Footnotes
    † Associate Director, Department of Clinical Pharmacology
    Affiliations
    From the Good Samaritan Regional Medical Center, Phoenix Children’s Hospital, Phoenix, Arizona
    Search for articles by this author
  • Author Footnotes
    * Director, Medical Toxicology Fellowship, Departments of Medical Toxicology, Pharmacy, and Medicine
    † Associate Director, Department of Clinical Pharmacology
DOI:https://doi.org/10.1016/S0749-0704(18)30296-3
Nitroprusside, Nitroglycerin, and Angiotensin-Converting Enzyme Inhibitors
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      Sodium nitroprusside causes cyanide poisoning at currently recommended infusion rates. Serum thiocyanate concentrations are of no value in detecting cyanide poisoning caused by nitroprusside. Methemoglobinemia in those patients receiving intravenous nitroglycerin may seriously impair oxygen delivery and is not always accompanied by cyanosis in anemic patients. Angiotensin-converting enzyme inhibitors are responsible for a plethora of adverse effects, including renal insufficiency, hypotension, angioedema, cough, and increased insulin sensitivity.
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      DOI: https://doi.org/10.1016/S0749-0704(18)30296-3

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