Advertisement
Research Article| Volume 7, ISSUE 3, P695-711, July 1991

Steroids and Biologic Agents in the Intensive Care Unit

  • Author Footnotes
    * Assistant Clinical Professor of Internal Medicine; and Director of Pulmonary Clinics and Invasive Bronchoscopy (Lasers)
    Roblee P. Allen
    Correspondence
    Address reprint requests to: Roblee P. Allen, MD, FACCP, Division of Pulmonary and Critical Care Medicine, University of California, Davis Medical Center, 2315 Stockton Boulevard, TR1219, Sacramento, CA 95817
    Footnotes
    * Assistant Clinical Professor of Internal Medicine; and Director of Pulmonary Clinics and Invasive Bronchoscopy (Lasers)
    Affiliations
    From the Division of Pulmonary and Critical Care Medicine, University of California, School of Medicine; and Davis Medical Center, Sacramento, California
    Search for articles by this author
  • Author Footnotes
    † Associate Professor of Internal Medicine, Chief, Division of Pulmonary and Critical Care Medicine; and Medical Intensive Care Unit and Regional Poison Center
    Timothy E. Albertson
    Footnotes
    † Associate Professor of Internal Medicine, Chief, Division of Pulmonary and Critical Care Medicine; and Medical Intensive Care Unit and Regional Poison Center
    Affiliations
    From the Division of Pulmonary and Critical Care Medicine, University of California, School of Medicine; and Davis Medical Center, Sacramento, California
    Search for articles by this author
  • Author Footnotes
    * Assistant Clinical Professor of Internal Medicine; and Director of Pulmonary Clinics and Invasive Bronchoscopy (Lasers)
    † Associate Professor of Internal Medicine, Chief, Division of Pulmonary and Critical Care Medicine; and Medical Intensive Care Unit and Regional Poison Center
DOI:https://doi.org/10.1016/S0749-0704(18)30301-4
Steroids and Biologic Agents in the Intensive Care Unit
Previous ArticleToxic Effects of Electrolyte and Trace Mineral Administration in the Intensive Care Unit
Next ArticleToxic Effects of Colloids in the Intensive Care unit
      This paper is only available as a PDF. To read, Please Download here.
      The term biologic pharmaceutical agents is used to define compounds that are naturally occurring physiologic substances or synthetic variations of naturally occurring subs.ances that have been adapted to therapeutic uses. This article reviews the pharmacologic mechanisms, actions, toxicity, and drug interactions of a number of examples from this important group of therapeutic agents.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Critical Care Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Addison T.
        On the constitutional and local effects of disease of the suprarenal capsules. Samuel Highley, London1855
        • Ahnalsyah I.
        • Salin A.
        Treatment of tetanus.
        Br Med J. 1985; 291: 648-650
        • Antman E.M.
        • Werger T.L.
        • et al.
        Treatment of 150 cases of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments.
        Circulation. 1990; 81: 1744-1752
        • Antman K.S.
        • Griffin J.D.
        • et al.
        Effect of recombinant human GM-CSF on chemotherapy-induced myelosuppression.
        N Engl J Med. 1988; 319: 553-598
        • Baumgartner J.D.
        • et al.
        Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin core glycolipid.
        Lancet. 1985; 94: 59-63
        • Behring E.
        • Boer A.
        • Kassel H.
        Zur behadlug diphtheriekranken menschen mit diphtherieheilserum.
        Dtsch Med Wochenschr. 1983; 17: 389-393
        • Blake P.A.
        • Feldman R.A.
        • Buchanan T.M.
        • et al.
        Serologic therapy for tetanus in the U.S..
        JAMA. 1976; 235: 42-44
        • Boulianne G.L.
        • Hoyeini N.
        • Shulman M.J.
        Production of functional chimaeric mouse/human antibody.
        Nature. 1984; 312: 643-646
        • Budman D.R.
        • Steinberg A.D.
        Hematologic aspects of SLE.
        Am Intern Med. 1977; 86: 220
        • Burke J.F.
        • et al.
        Immunosuppression and temporary skin transplantation in the treatment of massive third degree burns.
        Am Surg. 1975; 182: 183-197
        • Butler V.P.
        • Schmidt D.H.
        • Smith T.W.
        • et al.
        Effect of Fab fragments of sheep antidigoxin on serum concentration and urinary excretion.
        Circulation. 1973; 48: 130-136
        • Carpenter C.B.
        • Kirkman R.L.
        • et al.
        Prophylactive use of monoclonal anti-IL-2 receptor antibody in cadaveric renal transplant.
        Am J Kidney Dis. 1989; 14: 54-57
        • Cassan S.M.
        • Coles D.T.
        • Harreson E.G.
        The concept of limited forms of Wegener’s granulomatosis.
        Am J Med. 1970; 49: 366
        • Chai H.
        • Gilbert S.
        Effect of alternate-day prednisolone on the WBC in children with asthma or allergy.
        Clin Immun. 1973; 51: 65-70
        • Chia J.K.
        • et al.
        Botulism in an adult associated with food-borne intestinal infection with Clostridium.
        N Engl J Med. 1986; 315: 239-241
        • Cooperative Group for the Study oflmmunoglobulin in CLL
        Intravenous immunoglobulin for the prevention of infection in CLL.
        N Engl J Med. 1988; 319: 902-907
        • Cori C.F.
        • Cori G.I.
        The fate of sugar in the animal body. VII. The carbohydrate metabolism of adrenalectamized rats and mice.
        J Biol Chem. 1927; 74: 473-494
        • Damas P.
        • et al.
        Tumor necrosis factor and IL-1 serum levels during sepsis in humans.
        Crit Care Med. 1989; 17: 975-978
        • Daniels T.C.
        • Larson D.L.
        • et al.
        Serum protein profiles in thermal burns.
        J Trauma. 1974; 19: 137-152
        • Dellinger R.P.
        • Albertsen T.E.
        • Fischer C.
        • et al.
        Pharmacokinetics and safety of human monoclonal antibody HA-1A in presumptive septic patients.
        Abstracts of 1989 Interscience Conference Antimicrobial Agents and Chemotherapy #849. 1989; : 43
        • Dinarello C.A.
        • Okusawa S.
        • Geffand J.
        Interleukin I induces a shock-like state in rabbits: Synergism with TNF and the effect of cyclo-oxygenase inhibitor.
        Molecular and Cellular Mechanisms of Septic Shock. Alan R. Liss, New York1989: 243-262
        • Donahue R.E.
        • Wang E.A.
        • et al.
        Stimulation of hematopoiesis in primates by continuous infusion of recombinant human GM-CSF.
        Nature. 1986; 321: 872-875
        • Dunn D.L.
        • Ewald D.C.
        • Chardan N.
        • et al.
        Immunotherapy of gram-negative bacterial sepsis.
        Arch Surg. 1986; 121: 58-61
        • Duswald K.T.
        • Muller K.
        • Seifert J.
        • et al.
        Wirksankert non IV gammaglobulin gegen bakterielle infektumen chucergischer patrenten erybinasse liver kantrokerten randemisierten klinische studie.
        MMWR. 1980; 122: 832-836
        • Eaton O.M.
        • Stevens H.
        • Silver H.M.
        Respiratory failure in polyradiculoneuritis associated with mononucleosis.
        JAMA. 1965; 194: 609
        • Edsall G.
        Current states of tetanus immunization.
        Hosp Pract July. 1971; 6: 57-66
        • Fanta C.H.
        • Ressing T.H.
        • McFadden E.R.
        Glucocorticoids in acute asthma, a critical controlled trial.
        Am J Med. 1983; 74: 845
        • Feinglass E.J.
        • lamett F.C.
        • Dorsch C.A.
        • et al.
        Neuropsychiatric manifestation of SLE.
        Medicine. 1976; 55: 323
        • Filo R.S.
        • Smith E.J.
        • Leapman S.B.
        Therapy of acute cadaveric renal allograft rejection with adjunctive antilymphocyte globulin.
        Transplantation. 1980; 30: 445-449
        • Fujita T.
        • Harnyosi A.
        • et al.
        Antivenom effects of human lymphoblastoid interferon on advanced renal cell carcinoma.
        J Urol. 1988; 139: 256-258
        • Gayner E.R.
        • et al.
        Hemodynamic effects of treatment with IL-2 and lymphokine activated killer cells.
        Am Intern Med. 1988; 109: 953-958
        • Glinz W.
        • et al.
        Polyvalent immunoglobulins for prophylaxis of bacterial infections in patients following trauma.
        Intensive Care Med. 1985; 11: 288-294
        • Goodman L.S.
        • Gilman A.
        Pharmacologic Basis of Therapeutics. 1975; : 1485
        • Gupta P.S.
        • et al.
        Intrathecal human tetanus immunoglobulin in early tetanus.
        Lancet. 1980; 2: 439-440
        • Gutterman J.V.
        • et al.
        Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma and malignant lymphoma.
        Ann Intern Med. 1980; 93: 399406
        • Harrop G.A.
        • Soffer L.
        • et al.
        Studies of the suprarenal cortez III. Plasma electrolytes and electrolyte excretion during suprarenal insufficiency in the dog.
        J Exp Med. 1933; 58: 17-38
        • Harsting M.J.
        • et al.
        Determination of free digoxin concentrations in serum for monitoring FAB treatment of digoxin overdose.
        Clin Chem. 1987; 33: 1652-1655
        • Haskell R.J.
        • Bryan M.W.
        • Hansen J.E.
        A double-blind, randomized trial of methylprednisolone in studies of asthmatics.
        Arch Intern Med. 1983; 143: 1324-1327
        • Hench P.S.
        • et al.
        The effect of a hormone of the adrenal cortex and of pituitary ACTH on rheumatoid arthritis.
        Proc Staff Meeting Mayo Clin. 1949; 24: 181-197
        • Hill H.R.
        • Augustine N.H.
        • Slugeoka A.O.
        Comparative opsonization activity of IV gamma globulin preparation for common bacterial pathogens.
        Am J Med. 1984; 76: 61-66
        • Hinder G.G.
        • McDuffy F.C.
        • Hepper N.G.
        Pleural fluid complement in SLE & RA.
        Am Intern Med. 1972; 76: 357
        • Hooper R.G.
        • Kearl R.A.
        Established ARDS treated with a sustained course of adrenocortical steroids.
        Chest. 1990; 97: 138-143
        • Hughes J.M.
        • et al.
        Clinical features of type A & B food-borne botulism.
        Am Intern Med. 1981; 98: 442-445
        • Irvine W.J.
        • Barnes E.W.
        Adrenocortical insufficiency.
        Clin Endocrinol Metab. 1972; 1: 549
        • Isaacs A.
        Vims interference the interferon.
        Proc R Soc Lond (Biol. 1957; 147 (Lindenmann): 258-267
        • Johnson T.S.
        • et al.
        Prevention of acute mountain sickness by dexamethasone.
        N Engl J Med. 1984; 310: 683-686
        • Jurkovich G.J.
        • et al.
        Complications of Crotalidae antivenom therapy.
        J Trauma. 1988; 28: 1032-1037
        • Kefalides M.
        • et al.
        Role of infection in morality for severe burns.
        N Engl J Med. 1962; 267: 317-323
        • Keyter D.E.
        • Bunn D.J.
        • Pentel P.R.
        Monoclonal antibody effects on imipramine distribution in rats.
        Ann Emerg Med. 1990; 19: 629
        • Kirkman R.L.
        • Barrett L.V.
        • et al.
        Administration of an anti-interleukin-2 receptor monoclonal antibody prolongs cardiac allograft survival in mice.
        J Exp Med. 1986; 162: 358-362
        • Klipper A.R.
        • Stevens M.B.
        • et al.
        Ischemic necrosis of bone in SLE.
        Medicine. 1976; 55: 251
        • Kremer A.B.
        • Barnes L.
        • et al.
        Orthoclonal OKT3 monoclonal antibody reversal of hepatic and cardiac allograft rejection immunoresponsive to conventional immunosuppressive treatments.
        Trans Proc. 1987; 14: 254-257
        • Livanou T.
        • Ferrimon D.
        • Jones V.H.T.
        Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy.
        Lancet. 1967; 2: 856
        • Lipmen J.
        Autonomic dysfunction in severe tetanus.
        Crit Care Med. 1987; 15: 987-988
        • MacDonald K.L.
        • Spergler R.F.
        • Hatheway C.L.
        • et al.
        Type A botulism from sauteed onions.
        JAMA. 1985; 253: 1275-1283
        • Marks M.I.
        • Ziegler E.J.
        • Herndes D.
        • et al.
        Induction of immunity against Hemophilus influenzae type B infection by E. coli core lipopolysaccharide.
        J Clin Invest. 1982; 69: 742-749
        • Marogaretten W.
        • McAdams A.T.
        An appraisal of fulminant meningococcemia with reference to the Shwartzna phenomena.
        Am J Med. 1958; 25: 868
        • Mastropole P.L.
        • Grace W.J.
        Diagnostic and therapeutic considerations in hypercalcemic syndrome.
        Crit Care Med. 1976; 4: 20
        • Matthay R.A.
        • Scharz M.I.
        • Petty I.L.
        Pulmonary manifestations of SLE.
        Medicine. 1975; 54: 397
        • McFadden E.R.
        Pathogenesis of asthma.
        J Allergy Clin Immunol. 1984; 310: 1570
        • Morgan D.A.
        • Ruscetti F.W.
        • Gallo R.
        Selective in vitro growth of T lymphocytes from normal human bone marrows.
        Science. 1976; 193: 1007-1008
        • Murray J.E.
        • et al.
        Prolonged survival of human kidney homografts by immuno suppressive drug therapy.
        N Engl J Med. 1963; 208: 1315-1323
        • Payne V.W.
        • et al.
        Tetanus in the elderly.
        Intern Med. 1887; 8: 106-111
        • Pfeiffer R.
        • Kolle W.
        Ueber die spezifische immunitaetsreaktum der typhius-bacillen.
        Z Hyg Infektionskr. 1896; 21: 203-246
        • Pollock M.
        Antibody against Pseudomonas in immune globulins prepared for IV use in humans.
        J Infect Dis. 1983; 147: 1090-1098
        • Rosenblum M.G.
        • Donato N.J.
        Tumor necrosis factor and a multifaceted peptide hormone.
        Crit Rev Immunol. 1989; 9: 21-44
        • Schiff M.J.
        • Farber B.F.
        • Kaplan M.H.
        Steroids for pneumocystis pneumonia and respiratory failure in AIDS.
        Arch Intern Med. 1990; 150: 1819-1821
        • Schmidt D.H.
        • Butler V.P.
        Reversal of digoxin toxicity with specific antibodies.
        J Clin Invest. 1971; 50: 1738-1747
        • Sefkowitz R.J.
        • Caron M.C.
        • Stiles G.L.
        Mechanisms of membrane receptor regulation.
        N Engl J Med. 1984; 310: 1570
        • Shapiro H.M.
        Physiologic and pharmacologic regulation of cerebral blood flow. Refresher Course in Anesthesiology. JB Lippincott, Philadelphia1985: 161-178
        • Shawler D.L.
        • et al.
        Human immune response to multiple injection of murine chimeric IgG.
        J Immunol. 1985; 135: 1530-1535
        • Shirani K.Z.
        • et al.
        Replacement therapy with modified immunoglobulin in burn patients.
        Am J Med. 1984; 76: 175-180
        • Simone C.
        • Giovama D.
        • Geovanni C.
        IV immunoglobulins in association with antibiotics: A therapeutic trial in septic ICU patients.
        Crit Care Med. 1988; 16: 23-26
        • Simpson P.J.
        • Todde R.E.
        • et al.
        Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (Anti Mol, Anti CD11b) that inhibits leukocyte adhesion.
        J Clin Invest. 1988; 81: 624-629
        • Simpson S.A.
        • et al.
        Konstitution des aldosterons des neuen minerales-corticoids.
        Erperiontia. 1954; 10: 132-133
        • Smith T.W.
        • Haber M.D.
        • Yeatman L.
        • et al.
        Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies.
        N Engl J Med. 1976; 294: 797-800
        • Soulillou J.P.
        • et al.
        Randomized trial of a monoclonal antibody against IL-2 receptor as compared with rabbit ATG for prophylaxis against rejection of renal allografts.
        N Engl J Med. 1990; 322: 1175-1182
        • Spector S.L.
        • Katz F.H.
        • Farr R.S.
        TAO: Effectiveness in steroid-dependent asthma and bronchitis.
        J Allergy Clin Immun. 1974; 54: 367-379
        • Staten E.D.
        • Essner R.
        • Ecenomon J.S.
        Overview of biological response modifiers.
        Gen Surg One. 1989; 5: 379-384
        • Stere H.H.
        • et al.
        Evaluation of gammaglobulin for prophylaxis against bum sepsis.
        Surgery. 1965; 58: 810-814
        • Sulfrendini A.F.
        • et al.
        The cardiovascular response of normal humans to the administration of endotoxin.
        N Engl J Med. 1989; 321: 280-287
        • Stevens J.H.
        • Hanly O.
        • et al.
        Effects of anti C5A antibodies in ARDS in septic primates.
        J Clin Invest. 1986; 77: 1812-1816
        • Tacket C.O.
        • et al.
        Equine antitoxin use and other factors that predict outcome in Type A food-borne botulism.
        Am J Med. 1984; 76: 794-798
        • Trujillo M.H.
        • et al.
        Impact of intensive care management on the progression of tetanus.
        Chest. 1987; 92: 163-165
        • Vedder N.B.
        • Winn R.K.
        • et al.
        Monoclonal antibody to the adherence-promoting leukocyte glycoprotein CD 18 reduced organ injury and improved survival for hemorrhagic shock.
        J Clin Invest. 1981; 81: 939-944
        • Vroom F.Q.
        • Engel W.K.
        Non-neoplastic steroid responsive Lambert Eaton myasthenic syndrome.
        Neurology. 1969; 19: 281
        • Wasserman S.I.
        Mediators of immediate hypersensitivity.
        J Allergy Clin Immunol. 1983; 72: 101
        • Wayne L.
        Immunosuppressive agents in lupus nephritis.
        Medicine. 1976; 55: 239
        • Wanebo H.G.
        Tumor necrosis factors.
        General Surgical Oncology. 1989; 5: 402-413
        • Weinmaker T.L.
        • Becker Z.L.
        • Katz S.
        Endocrine aspects of sarcoidosis.
        N Engl J Med. 1968; 278: 427
        • Weishart R.H.
        • Golde D.W.
        • et al.
        Human GM-CSF is a neutrophil activator.
        Nature. 1985; 314: 361-363
        • Wingert W.A.
        • Chan L.
        Rattlesnake bites in southern California and rationals for recommended treatment.
        West J Med. 1988; 148: 37-44
        • Winkelmann R.K.
        • et al.
        Management of scleroderma.
        Mayo Clin Proc. 1971; 46: 128
        • Wynne I.W.
        • Modell T.H.
        Respiratory aspiration of stomach contents.
        Am Intern Med. 1977; 87: 466
        • Ziegler E.J.
        • McCutchan J.A.
        • Fierer j.
        • et al.
        Treatment of gram-negative bacteremia and shock with human antisemm to a mutant E. coll..
        N Engl J Med. 1982; 307: 1225-1230
        • Zuckerman G.R.
        • Cert D.
        • Sherman R.B.
        Stress ulcer syndrome.
        Intensive Care Med. 1988; 2: 21-31

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0749-0704(18)30301-4

      Copyright

      © 1991 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX