Research Article| Volume 7, ISSUE 1, P109-125, January 1991

Diabetes Insipidus

  • K. Patrick Ober
    Address reprint requests to: K. Patrick Ober, MD, Department of Internal Medicine, Bowman Gray School of Medicine of Wake Forest University, 300 S. Hawthorne Road, Winston-Salem, NC 27103
    Associate Professor of Medicine, Department of Internal Medicine, Section on Endocrinology and Metabolism, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina
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      Normal water balance is dependent on intact function of osmoreceptors. Abnormalities in osmolality trigger alterations in ADH secretion and in the thirst drive. Diabetes insipidus is a common consequence of head trauma, neurosurgical procedures, and other types of pathology. The diagnosis is based on thoughtful evaluation of the relationship between serum osmolality, urine osmolality, and ADH levels. Appropriate management includes careful monitoring, replacement of free water, and cautious replacement of ADH.
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