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Both a rapid onset and rapid correction of hyponatremia can cause brain damage. Emergency
treatment should be reserved for patients who present with seizures and coma, and
patients who develop any neurologic symptoms while receiving intravenous fluids. In
such cases, 3% saline solution should be given at 1 to 2 mL/kg/h, but after 2 to 3
hours, the rate of correction of hyponatremia can be slowed to avoid an increase of
more than 12 mEq/L during the first day of therapy.
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© 1991 Elsevier Inc. Published by Elsevier Inc. All rights reserved.