Advertisement
Research Article| Volume 7, ISSUE 1, P155-174, January 1991

Hyperkalemia

  • Mark E. Williams
    Correspondence
    Address reprint requests to: Mark E. Williams, MD, FACP Joslin Diabetes Center (Renal Unit), 1 Joslin Place, Boston, MA 02215
    Affiliations
    Chief of Dialysis, New England Deaconess Hospital; and Assistant Professor of Medicine, Harvard Medical School, Boston, Massachusetts
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.
      Normal potassium homeostasis depends on maintenance of its internal and external balance. The primary organ for preserving external K balance is the kidney; internal factors primarily include insulin, catecholamines, and acidosis. Patients at risk for hyperkalemia include those with renal failure, diabetes mellitus, hyporenin- emic hypoaldosteronism, or on a variety of drugs. The cardiac effects of severe hyperkalemia may require urgent therapy in a critical care setting. Because hyperkalemia has many causes, an organized approach is necessary to determine the underlying cause.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Critical Care Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Adu D.
        • Michael J.
        • Turney J.
        Hyperkalemia in cyclosporine-treated renal allograft recipients.
        Lancet. 1983; 2: 370
        • Allon M.
        • Dunlay R.
        • Copkney C.
        Nebulized albuterol for acute hyperkalemia in patients on hemodialysis.
        Ann Intern Med. 1989; 110: 426
        • Arrizabalaga P.
        • Montoliu J.
        • Martinez-Vea A.
        • et al.
        Increase in serum potassium caused by beta-2 adrenergic blockade in terminal renal failure: Absence of mediation by insulin or aldosterone [abstract].
        Kidney lire. 1983; 24: 427
        • Bailie D.C.
        • Arruda J.A.L.
        • Kurtzman N.A.
        Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy.
        N Engl J Med. 1981; 304: 373
        • Batlle D.
        • Itsarayoungyuen K.
        • Arruda J.A.L.
        • et al.
        Hyperkalemic hyperchloremic metabolic acidosis in sickle cell hemoglobinopathies.
        Am J Med. 1982; 72: 188
        • Bia M.J.
        • DeFronzo R.A.
        Extrarenal potassium homeostasis.
        Am J Physiol. 1981; 240: F257
        • Bismuch C.
        • Gaultier M.
        • Conso F.
        Hyperkalemia in acute digitalis poisoning: Prognostic significance and therapeutic implications.
        Clin Toxic. 1973; 6: 153
        • Brown M.
        Hypokalemia from beta2-receptor stimulation by circulating epinephrine.
        Am J Cardiol. 1985; 56: 30
        • Bunning R.D.
        • Werner F.B.
        Sulindac: A potential renal-sparing nonsteroidal antiinflammatory drug.
        JAMA. 1982; 248: 2864
        • Bushinsky D.A.
        • Gennari F.J.
        Life-threatening hyperkalemia induced by arginine.
        Ann Intern Med. 1978; 89: 632
        • Chakko S.C.
        • Frutchey J.
        • Cheorghiade M.
        Life-threatening hyperkalemia in severe heart failure.
        Am Heart J. 1989; 117: 1083
        • Clausen T.
        Adrenergic control of Na+-K+ homeostasis.
        Acta Med Scand (suppl. 1983; 672: 111
        • Cogan M.C.
        • Arieff A.l.
        Sodium-wasting, acidosis, and hyperkalemia induced by methicillin interstitial nephritis: Evidence for selective distal tubular dysfunction.
        Am J Med. 1978; 64: 500
        • Cohen A.B.
        Hyperkalemic effects of triamterene.
        Ann Intern Med. 1961; 65: 521
        • Cohen L.F.
        • Balow J.E.
        • Magrath I.T.
        • et al.
        Acute tumor lysis syndrome.
        Am J Med. 1980; 68: 486
        • DeFronzo R.A.
        • Cooke C.R.
        • Goldberg M.
        • et al.
        Impaired renal tubular potassium secretion in systemic lupus erythematosus.
        Ann Intern Med. 1977; 86: 268
        • DeFronzo R.A.
        • Felig P.
        • Ferrannini E.
        • et al.
        Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man.
        Am J Physiol. 1980; 238: E421
        • DeFronzo R.A.
        • Goldberg M.
        • Cooke C.R.
        • et al.
        Investigations into the mechanisms of hyperkalemia following renal transplantation.
        Kidney Int. 1977; 11: 357
        • DeFronzo R.A.
        • Sherwin R.S.
        • Dillingham M.
        • et al.
        Influence of basal insulin and glucagon secretion on potassium and sodium metabolism.
        J Clin Invest. 1978; 61: 472
        • DeLeiva A.
        • Christlieb R.
        • Melby J.C.
        • et al.
        Big renin and biosynthetic defect of aldosterone in diabetes mellitus.
        N Engl J Med. 1976; 295: 639
        • Don B.R.
        • Sebastian A.
        • Cheiltlin M.
        • et al.
        Pseudohyperkalemia caused by fist clenching during phlebotomy.
        N Engl J Med. 1990; 322: 1290
        • Elkinton J.R.
        • Danowski T.S.
        The body fluids.
        Basic Physiology and Practical Therapeutics. Williams & Wilkins, Baltimore1955
        • Ettinger P.O.
        • Regan T.J.
        • Oldewartel H.A.
        Hyperkalemia, cardiac conduction, and the electrocardiogram: A review.
        Am Heart J. 1974; 88: 360
        • Fozzard H.A.
        Excitable membranes.
        in: Seldin D.W. Giebisch G. The Kidney. Normal and Abnormal Function. Raven Press, New York1985
        • Fulop M.
        Serum potassium in lactic acidosis and ketoacidosis.
        N Engl J Med. 1979; 200: 1087
        • Gavryck W.A.
        • Moore R.D.
        • Thompson R.C.
        Effect of insulin upon membrane-bound (Na+-K+)-ATPase extracted from frog skeletal muscle.
        J Physiol. 1975; 252: 43
        • Goldfarb S.
        • Cox M.
        • Singer I.
        • et al.
        Acute hyperkalemia induced by hyperglycemia: Hormonal mechanisms.
        Ann Intern Med. 1976; 84: 426
        • Goldszer R.C.
        • Coodlley E.L.
        • Rosner M.J.
        • et al.
        Hyperkalemia associated with indomethacin.
        Arch Intern Med. 1980; 141: 802
        • Gonick H.C.
        • Kleeman C.R.
        • Rubini M.E.
        • et al.
        Functional impairment in chronic renal disease. III. Studies of potassium excretion.
        Am J Med Sci. 1971; 261: 281
        • Guerra S.
        • Kitabchi A.E.
        Comparison of the effectiveness of various routes of insulin injection: Insulin levels and glucose response in normal subjects.
        J Clin Endocrinol Metab. 1976; 42: 869
        • Hertz P.
        • Richardson J.
        Arginine-induced hyperkalemia.
        Arch Intern Med. 1972; 130: 778
        • Hirsch D.
        • Kashgarian M.
        • Boulpaep E.L.
        • et al.
        Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule.
        Kidney Int. 1984; 26: 798
        • Ho-Yen D.O.
        • Pennington C.R.
        Pseudohyperkalemia and infectious mononucleosis.
        Postgrad Med J. 1980; 56: 435
        • Jamison R.L.
        • Lacy F.B.
        • Pennell J.P.
        • et al.
        Potassium secretion by the descending limb of pars recta of the juxtamedullary nephron in vivo.
        Kidney Int. 1976; 9: 323
        • Kliger A.S.
        • Hayslett J.P.
        Disorders of potassium balance.
        in: Brenner B.M. Stein J.N. Contemporary Issues in Nephrology. vol 2. Churchill Livingstone, New York1978: 168 (Acid-Base and Potassium Homeostasis)
        • Landsberg L.
        • Young J.B.
        Fasting, feeding, and regulation of the sympathetic nervous system.
        N Engl J Med. 1978; 298: 1295
        • Lankton J.W.
        • Siler J.N.
        • Neigh J.L.
        Hyperkalemia after administration of potassium from nonrigid parenteral-fluid containers.
        Anesthesia. 1973; 39: 660
        • Levine H.D.
        Electrolyte imbalance and the ECG.
        Mod Cone Cardiovas Dis. 1954; 23: 246
        • Luke R.G.
        • Allison M.E.
        • Davison J.R.
        • et al.
        Hyperkalemia and renal tubular acidosis due to renal amyloidosis.
        Ann Intern Med. 1969; 70: 1211
        • Maddux B.D.
        • Whiting R.B.
        Toxic synergism of disopyramide and potassium.
        Chest. 1980; 78: 654
        • Madias N.
        Lactic acidosis.
        Kidney Int. 1986; 29: 752
        • Maher T.
        • Schambelan M.
        • Kurtz I.
        • et al.
        Amelioration of metabolic acidosis by dietary potassium restriction in hyperkalemic patients with chronic renal insufficiency.
        J Lab Clin Med. 1984; 103: 432
        • Malnic G.
        • Klose R.M.
        • Giebisch G.
        Micropuncture study of renal potassium excretion in the rat.
        Am J Physiol. 1964; 206: 674
        • Manning R.T.
        • Behrle F.C.
        Use of spironolactone in renal edema; effectiveness and association with hyperkalemia.
        JAMA. 1961; 176: 769
        • Maslowsld A.H.
        • Ikram H.
        • Nicholls M.G.
        • et al.
        Haemodynamic, hormonal, and electrolyte responses to captopril in resistant heart failure.
        Lancet. 1981; 1: 71
        • Massara F.
        • Martelli S.
        • Cagliero E.
        • et al.
        Influence of glucagon on plasma levels of potassium in man.
        Diabetologia. 1980; 19: 414
        • Miller C.E.
        • Remenchik A.P.
        Problems involved in accurately measuring the K content of the human body.
        Ann NY Acad Sci. 1963; 110: 175
        • Moreno M.
        • Murphy C.
        • Goldsmith C.
        Increase in serum potassium resulting from the administration of hypertonic mannitol and other solutions.
        J Lab Clin Med. 1968; 73: 291
        • Mulligan I.
        • Parfrey F.
        • Phillips M.E.
        • et al.
        Acute haemolysis due to concentrated dialysis fluid.
        Br Med J. 1982; 284: 1151
        • Nerup J.
        Addison’s disease. A report of 108 cases.
        Acta Endocrinol. 1974; 76: 127
        • Noth R.H.
        • Lassman M.N.
        • Tan S.
        • et al.
        Age and the renin-aldosterone system.
        Arch Intern Med. 1977; 137: 1414
        • Oberleithner H.
        • Kubota T.
        • Giebisch G.
        Potassium (K+) transport and intracellular K+ activity in distal tubules of Amphiuma [abstract].
        Fed Proc. 1980; 39: 1079
        • Oh M.S.
        • Uribarri J.
        • Carrol H.J.
        Hyperkalemia in organic acidosis.
        Proc Am Soc Nephrol. 1984; : 50A
        • Oster J.R.
        • Perez G.O.
        • Castro A.
        • et al.
        Plasma potassium response to acute metabolic acidosis induced by mineral and nonmineral acids.
        Miner Electrolyte Metab. 1980; 4: 28
        • Perez G.
        • Lespier L.
        • Knowles R.
        • et al.
        Hyporeninemia and hypoaldosteronism in diabetes mellitus.
        Arch Intern Med. 1977; 137: 852
        • Perez G.O.
        • Oster J.R.
        • Pelleya R.
        • et al.
        Hyperkalemia from single oral doses of potassium chloride.
        Nephron. 1984; 36: 270
        • Perez G.O.
        • Oster J.R.
        • Vaamonde C.A.
        Serum potassium concentration in acidemic states.
        Nephron. 1981; 27: 233
        • Petcah M.C.
        • McKay R.
        • Bethune D.W.
        The effect of beta2 adrenergic blockade on serum potassium and glucose levels during open heart surgery.
        Eur Heart J. 1981; 2: 123
        • Peterson K.C.
        • Silberman H.
        • Berne T.V.
        Hyperkalemia after cyclosporine therapy.
        Lancet. 1984; 1: 1470
        • Pollen R.H.
        • Williams R.H.
        Hyperkalemic neuromyopathy in Addison’s disease.
        N EnglJ J Med. 1960; 263: 273
        • Rimmer J.M.
        • Horn J.F.
        • Gennari J.
        Hyperkalemia as a complication of drug thernpy.
        Arch Intern Mecf. 1987; 14-7: 867
        • Rosa R.M.
        • Silva F.
        • Young J.B.
        • et al.
        Adrenergic modulation of excrarenal potassium disposal.
        N Engl J Med. 1980; 302: 431
        • Schambelan M.
        • Stockigt J.R.
        • Biglieri E.G.
        Isolated hypoaldosteronism.
        N Engl J Med. 1972; 287: 573
        • Schwartz W.B.
        Potassium and the kidney.
        N Engl J Med. 1955; 253: 601
        • Scribner B.H.
        • Burnell J.
        Interpretation of the serum potassium concentration.
        Metabolism. 1956; 5: 468
        • Scribner B.H.
        • Fremont-Smith K.
        • Burnell J.M.
        The effect of acute respiratory acidosis on the internal equilibrium of potassium.
        N Engl J Med. 1955; 34: 1276
        • Silva P.
        • Brown R.S.
        • Epstein F.H.
        Adaptation to potassium.
        Kidney Int. 1977; 11: 466
        • Stanton B.
        • Guggino W.
        • Giebisch G.
        Acidification of the basolateral solution reduces potassium (K) conductance of the apical membrane [abstract].
        Fed Proc. 1982; 41: 1006
        • Sterns R.H.
        • Cox M.
        • Fieg P.U.
        • et al.
        Internal potassium balance and the control of the plasma potassium concentration.
        Medicine. 1981; 60: 339
        • Striker T.W.
        • Morrow A.G.
        Effect of succinylcholine on the level of serum potassium in man.
        Anesthesiology. 1968; 29: 214
        • Struthers A.D.
        • Reid J.L.
        Adrenaline causes hypokalemia in man by beta-2 adrenoreceptor stimulation.
        Clin Endocrinol. 1984; 20: 409
        • Surawicz B.
        Relationship between electrocardiogram and electrolytes.
        Am Heart J. 1967; 73: 814
        • Szylman P.
        • Better O.S.
        • Chaimawitz C.
        • et al.
        Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism.
        N Engl J Med. 1976; 294: 361
        • Tan S.Y.
        • Burton M.
        Hyporeninemic hypoaldosteronism: An overlooked cause of hyperkalemia.
        Arch Intern Med. 1981; 141: 30
        • Tan S.Y.
        • Shapiro R.
        • Franco R.
        • et al.
        Indomethacin-induced prostaglandin inhibition with hyperkalemia: A reversible cause of hyporeninemic hypoaldosterone.
        Ann Intern Med. 1979; 90: 783
        • Tannen R.L.
        Potassium homeostasis (part I.
        in: Massry SG Glassock RJ Textbook of Nephrology. Williams & Wilkins, Baltimore1983: 31
        • Textor S.C.
        • Bravo E.L.
        • Fouad F.
        • et al.
        Hyperkalemia in azotemic patients during angiotensin converting enzyme inhibition and aldosterone reduction with captopril.
        Am J Med. 1982; 73: 719
        • Velazquez H.
        • Wright F.S.
        • Good D.W.
        Luminal influences on potassium secretion: Chloride replacement with sulfate.
        Am J Physiol. 1982; 242: F46
        • Vincent H.H.
        • Boomsma F.
        • Man int Veld Veld A.J.
        • et al.
        Effects of selective and nonselective β-agonists on plasma potassium and norepinephrine.
        J Cardiovasc Pharmacol. 1984; 6: 107
        • Waal-Manning H.J.
        Metabolic effects of β-adrenergic blockers.
        Drugs. 1976; 11 (suppl 1): 121
        • Wetli C.V.
        • Davis J.W.
        Fatal hyperkalemia from accidental overdose of potassium chloride [letter].
        JAMA. 1978; 240: 1339
        • Whiting G.
        • McLaran C.
        • Bochner F.
        Severe hyperkalemia with moduretic.
        Med J Austr. 1979; 1: 409
        • Williams M.E.
        • Gervino E.V.
        • Rosa R.M.
        • et al.
        Catecholamines modulate rapid potassium shifts during exercise.
        N Engl J Med. 1985; 312: 823
        • Williams M.E.
        • Rosa R.M.
        • Epstein F.H.
        Hyperkalemia.
        in: Stollerman G. Advances in Internal Medicine. Year Book Medical Publishers, Chicago1986: 265
        • Wilson I.D.
        • Goetz F.C.
        Selective hypoaldosteronism after prolonged heparin administration.
        Am J Med. 1964; 36: 635