Advertisement
Research Article| Volume 2, ISSUE 4, P791-805, October 1986

Massive Transfusion

DOI:https://doi.org/10.1016/S0749-0704(18)30580-3
Massive Transfusion
Previous ArticleSpecial Problems in Management of Pediatric Trauma
Next ArticleThe Role of Nutrition in the Management of Metabolic Stress
      This paper is only available as a PDF. To read, Please Download here.
      Massive transfusion is a potentially serious problem associated with a number of complications, including changes in coagulation factor and platelet concentration, nonmechanical bleeding, hypothermia, pulmonary dysfunction, hypokalemia and hyperkalemia, hypocalcemia, hypomagnesemia, acidosis and alkalosis, immune suppression, blood transfusion reactions, and transmission of infectious diseases. The pathophysiology and management of massive transfusion are reviewed in this article.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.

      Subscribe:

      Subscribe to Critical Care Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Abbott T.
        Changes in serum calcium fractions and citrate concentrations during massive blood transfusions and cardiopulmonary bypass.
        Br. J. Anaesthesiol. 1983; 55: 753
        • Alter H.
        • Tabor E.
        • Meryman H.
        • et al.
        Transmission of hepatitis B virus infection by infusion of frozen deglycerolized red blood cells.
        N. Engl. J. Med. 1978; 298: 637
        • Arnow P.
        • Weiss L.
        • Weil D.
        • et al.
        Escherichia coli sepsis from contaminated platelet transfusion.
        Arch. Intern. Med. 1986; 146: 321-324
        • Barker L.
        Posttransfusion hepatitis: Epidemiology, experimental studies and U.S. perspectives.
        Bibl. Haematologica. 1980; 46: 3
        • Bisio J.
        • Connell R.
        • Harrison M.
        The formation and effect of stored platelet concentrate microemboli on pulmonary ultrastructure.
        Surg. Gynecol. Obstet. 1982; 154: 342-347
        • Borland L.
        • Roule M.
        • Cook D.
        Anesthesia for pediatric orthotopic liver transplantation.
        Anesth. Analg. 1985; 64: 117-124
        • Bryan-Brown C.
        • Bracey A.
        • Lorimor K.
        Intraoperative monitoring of the liver transplant patient.
        Acute Care. 1983–1984; 10: 207-212
        • Bunker J.
        • Bendixen H.
        • Murphy A.
        Hemodynamic effects of intravenously administered sodium citrate.
        N. Engl. J. Med. 1962; 266: 373
        • Carmichael D.
        • Hosty T.
        • Kastl D.
        • et al.
        Hypokalemia and massive transfusion.
        South. Med. J. 1984; 77: 315-317
        • De Rie M.
        • Van der Plas van Dalen C.
        • Engelfriet C.
        The serology of febrile transfusion reactions.
        Vox Sang. 1985; 49: 126-134
        • Hajiro K.
        • Matsui H.
        • Tsujimura D.
        • et al.
        Endoscopic bipolar electrocoagulation in massive upper gastrointestinal bleeding.
        Gastroenterol. Jpn. 1985; 20: 65-70
        • Harrigan C.
        • Lucas C.
        • Ledgerwood A.
        • et al.
        Serial changes in primary hemostasis after massive transfusion.
        Surgery. 1985; 98: 836-844
        • Heldebrant C.
        • Gomperts E.
        • Kaspar C.
        • et al.
        Evaluation of two viral inactivation methods for the preparation of safer factor VIII and factor IX concentrates.
        Transfusion. 1985; 25: 510-515
        • Hewson J.
        Homeostatic alterations with major trauma.
        Can. Anaesth. Soc. J. 1985; 32: 239-240
        • Hewson J.
        • Neame P.
        • Kumar N.
        • et al.
        Coagulopathy related to dilution and hypotension during massive transfusion.
        Crit. Care Med. 1985; 13: 387-391
        • Howland W.
        • Schweizer O.
        • Carlon G.
        • et al.
        Cardiovascular effects of low levels of ionized calcium during massive transfusion.
        Surg. Gynecol. Obstet. 1977; 145: 581
        • Johnson S.
        • Lucas C.
        • Gerrick S.
        • et al.
        Altered coagulation after albumin supplements for treatment of oligemic shock.
        Arch. Surg. 1979; 114: 379-383
        • Kahn R.
        • Juscott D.
        • Graziano C.
        • et al.
        Massive blood replacement: Correlation of ionized calcium, citrate, and hydrogen ion concentration.
        Anesth. Analg. 1979; 58: 274
        • Krome R.
        Resuscitation of the multiply injured patient.
        Emerg. Med. Clin. North Am. 1983; 1: 571-582
        • Lee T.
        • Lun K.
        Review of problems of massive blood transfusion in a surgical intensive care unit.
        Ann. Acad. Med. Singapore. 1985; 14: 175-184
        • Linko K.
        • Tigerstedt I.
        Hyperpotassemia during massive blood transfusions.
        Acta Anaesthesiol. Scand. 1984; 28: 220-221
        • Lovric V.
        Alterations in blood components during storage and their clinical significance.
        Anaesth. Intensive Care. 1984; 12: 246-251
        • Lucas C.
        • Ledgerwood A.
        • Eberhard F.
        Altered coagulation protein content after albumin resuscitation.
        Ann. Surg. 1982; 196: 198-203
        • Ludbrook J.
        • Wynn V.
        Citrate intoxication.
        Br. Med. J. 1958; 2: 523
        • Mannucci P.
        • Federici A.
        • Sirchia G.
        Hemostasis testing during massive blood replacement.
        Vox Sang. 1982; 42: 113-123
        • Martin D.
        • Lucas C.
        • Ledgerwood A.
        • et al.
        Fresh frozen plasma supplement to massive red blood cell transfusion.
        Ann. Surg. 1985; 202: 505-511
        • McClellan B.
        • Reid S.
        • Lane P.
        Massive blood transfusion causing hvpomagnesemi a.
        Crit. Care Med. 1984; 12: 146-147
        • Menitove J.
        • McElligott M.
        • Aster R.
        Febrile transfusion reaction: What blood component should be given next?.
        Vox Sang. 1982; 42: 318-321
        • Moffitt E.
        • Sethra D.
        • Gray R.
        • et al.
        Effects of calcium on the coronary and systemic circulation in patients after coronary surgery.
        Can. Anaesth. Soc. J. 1982; 29: 313
        • Murphy S.
        • Martinez J.
        • Holhurn R.
        Stability of plasma fibrinogen during storage of platelet concentrates at 22 degrees C.
        Transfusion. 1983; 23: 480-483
        • Noe T.
        • Graham S.
        • Luff R.
        • et al.
        Platelet counts during rapid massive transfusion.
        Transfusion. 1982; 22: 392-395
        • Penetta T.
        • Sclafani S.
        • Goldstein A.
        • et al.
        Percutaneous transcatheter embolization for massive bleeding from pelvic fractures.
        J. Trauma. 1985; 25: 1021-1029
        • Patten E.
        • Reddi C.
        • Riglin H.
        • et al.
        Delayed hemolytic transfusion reaction caused by a primary immune response.
        Transfusion. 1982; 22: 248-250
        • Pineda A.
        • Brzica S.
        • Taswell H.
        Hemolytic transfusion reaction. Recent experience in a large blood bank.
        Mayo Clin. Proc. 1978; 53: 378-390
        • Pineda A.
        • Taswell H.
        • Brzica S.
        Transfusion reaction. An immunologic hazard of blood transfusion.
        Transfusion. 1978; 18: 1-7
        • Reed R.
        • Ciavarella B.
        • Heimbach D.
        • et al.
        Prophylactic platelet administration during massive transfusion.
        Ann. Surg. 1986; 203: 40-48
        • Rush B.
        • Lee N.
        Clinical presentation of nonhaemolytic transfusion reactions.
        Anaesth. Intensive Care. 1980; 8: 125-131
        • Siegman I.
        Late postoperative fever—viral infection following multiple blood transfusion.
        Isr. J. Med. Sci. 1983; 19: 267-270
        • Skillman J.
        Tee of colloid in massive transfusions.
        in: Strauss R.G. Massive Transfusion in Surgery and Trauma. Alan R. Liss, Inc., New York1982: 65-68
        • Strauss R.
        Review of the effects of hvdroxyethyl starch on the blood coagulation system.
        Transfusion. 1981; 21: 299-302
        • Stulz P.
        • Scheidegger Z.
        • Drop L.
        • et al.
        Ventricular pump performance during hypocalcemia.
        J. Thorac. Cardiovasc. Surg. 1979; 78: 185
        • Taddie S.
        • Barrasso C.
        • Ness P.
        A delayed transfusion reaction caused by anti-K6.
        Transfusion. 1982; 22: 68-69
        • Takaki A.
        • Kato H.
        • Takeda S.
        • et al.
        The role of disseminated intravascular coagulation in shock induced by transfusion of human blood in dogs.
        Transfusion. 1979; 19: 404-410
        • Warden G.
        • Ninneman J.
        • Stratta R.
        • et al.
        The effect of exchange therapy on postburn lymphocyte suppression.
        Surgery. 1984; 96: 321-329

      Article info

      Identification

      DOI: https://doi.org/10.1016/S0749-0704(18)30580-3

      Copyright

      © 1986 Elsevier Inc. Published by Elsevier Inc. All rights reserved.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX