Neurocritical Care Research

Collaborations for Curing Coma
Published:October 06, 2022DOI:


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.

      Content published before 2002 is available via pay-per-view purchase only.


      Subscribe to Critical Care Clinics
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Posner J.B.
        • Saper C.B.
        • Schiff N.D.
        • et al.
        Plum and Posner's diagnosis and treatment of stupor and coma.
        Fifth edition. Oxford University Press, Oxford ; New York2019
        • Young G.B.
        • Ropper A.H.
        • Bolton C.F.
        Coma and impaired consciousness : a clinical perspective.
        McGraw-Hill, Health Professions Division, New York1998
        • Sanders R.D.
        • Tononi G.
        • Laureys S.
        • et al.
        Unresponsiveness not equal unconsciousness.
        Anesthesiology. 2012; 116: 946-959
        • Provencio J.J.
        • Hemphill J.C.
        • Claassen J.
        • et al.
        The curing coma campaign: framing initial scientific challenges-proceedings of the first curing coma campaign scientific advisory council meeting.
        Neurocrit Care. 2020; 33: 1-12
        • Giacino J.T.
        • Fins J.J.
        • Laureys S.
        • et al.
        Disorders of consciousness after acquired brain injury: the state of the science.
        Nat Rev Neurol. 2014; 10: 99-114
        • Kondziella D.
        • Bender A.
        • Diserens K.
        • et al.
        European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness.
        Eur J Neurol. 2020; 27: 741-756
        • Giacino J.T.
        The vegetative and minimally conscious states: consensus-based criteria for establishing diagnosis and prognosis.
        NeuroRehabilitation. 2004; 19: 293-298
        • Dauberschmidt R.
        • Zinsmeyer J.
        • Mrochen H.
        • et al.
        Changes of neuron-specific enolase concentration in plasma after cardiac arrest and resuscitation.
        Mol Chem Neuropathol. 1991; 14: 237-245
      1. Bangshoj J, Liebetrau B, Wiberg S, et al. The value of the biomarkers neuron-specific enolase and S100 calcium-binding protein for prediction of mortality in children resuscitated after cardiac arrest, Pediatr Cardiol, 2022: 1-7 (epub ahead of print).

        • Schiff N.D.
        Recovery of consciousness after brain injury: a mesocircuit hypothesis.
        Trends Neurosci. 2010; 33: 1-9
        • Norton L.
        • Hutchison R.M.
        • Young G.B.
        • et al.
        Disruptions of functional connectivity in the default mode network of comatose patients.
        Neurology. 2012; 78: 175-181
        • Kondziella D.
        • Fisher P.M.
        • Larsen V.A.
        • et al.
        Functional MRI for assessment of the default mode network in acute brain injury.
        Neurocrit Care. 2017; 27: 401-406
        • Luppi A.I.
        • Cain J.
        • Spindler L.R.B.
        • et al.
        Mechanisms underlying disorders of consciousness: bridging gaps to move toward an integrated translational science.
        Neurocrit Care. 2021; 35: 37-54
        • Oizumi M.
        • Albantakis L.
        • Tononi G.
        From the phenomenology to the mechanisms of consciousness: integrated information theory 3.0.
        PLoS Comput Biol. 2014; 10: e1003588
        • Mashour G.A.
        • Roelfsema P.
        • Changeux J.P.
        • et al.
        Conscious processing and the global neuronal workspace hypothesis.
        Neuron. 2020; 105: 776-798
        • Lant N.D.
        • Gonzalez-Lara L.E.
        • Owen A.M.
        • et al.
        Relationship between the anterior forebrain mesocircuit and the default mode network in the structural bases of disorders of consciousness.
        Neuroimage Clin. 2016; 10: 27-35
      2. Coulborn S, Taylor C, Naci L, et al. Disruptions in effective connectivity within and between default mode network and anterior forebrain mesocircuit in prolonged disorders of consciousness. Brain Sci 2021; 11(6): 749.

        • Olson D.M.
        • Hemphill 3rd, J.C.
        • Curing Coma C.
        • et al.
        The curing coma campaign: challenging the paradigm for disorders of consciousness.
        Neurocrit Care. 2021; 35: 1-3
        • Kondziella D.
        • Menon D.K.
        • Helbok R.
        • et al.
        A Precision medicine framework for classifying patients with disorders of consciousness: advanced classification of consciousness endotypes (ACCESS).
        Neurocrit Care. 2021; 35: 27-36
        • Claassen J.
        • Akbari Y.
        • Alexander S.
        • et al.
        Proceedings of the first curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness.
        Neurocrit Care. 2021; 35: 4-23
      3. Mainali S, Aiyagari V, Alexander S, et al. Proceedings of the second curing coma campaign nih symposium: challenging the future of research for coma and disorders of consciousness. Neurocrit Care 2022;37(1):326-350.

      4. Lewis A, Claassen J, Illes J, et al. Ethics priorities of the curing coma campaign: an empirical survey. Neurocrit Care 2022;37(1):12-2123.

      5. Helbok R, Rass V, Beghi E, et al. The curing coma campaign international survey on coma epidemiology, evaluation, and therapy (COME TOGETHER). Neurocrit Care 2022;37, pages 47-59. (2022)

        • Hammond F.M.
        • Katta-Charles S.
        • Russell M.B.
        • et al.
        Research needs for prognostic modeling and trajectory analysis in patients with disorders of consciousness.
        Neurocrit Care. 2021; 35: 55-67