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Pediatric Critical Care Outcomes

State of the Science
  • Mallory A. Perry-Eaddy
    Correspondence
    Corresponding author.
    Affiliations
    University of Conneticut School of Nursing, 231 Glenbrook Road, U-4026, Storrs, CT 06269, USA

    Department of Pediatrics, University of Connecticut School of Medicine, 200 Academic Way, Farmington, CT 06032, USA
    Search for articles by this author
  • Leslie A. Dervan
    Affiliations
    Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington, Seattle Children’s Hospital, M/S FA2.112, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Search for articles by this author
  • Joseph C. Manning
    Affiliations
    Paediatric Critical Care Outreach, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus, Derby Road, Nottingham, NG7 2UH, UK

    Centre for Children and Young People Health Research, School of Health Sciences, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, NG7 2HA, UK
    Search for articles by this author
  • R. Scott Watson
    Affiliations
    Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington, Seattle Children’s Hospital, M/S FA2.112, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Search for articles by this author
  • Martha A.Q. Curley
    Affiliations
    Department of Family and Community Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA 19104, USA

    Children’s Hospital of Philadelphia Research Institute, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA

    Department of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Search for articles by this author
Published:November 02, 2022DOI:https://doi.org/10.1016/j.ccc.2022.09.007

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      References

        • Epstein D.
        • Brill J.E.
        A history of pediatric critical care medicine.
        Pediatr Res. 2005; 58: 987-996
        • Heneghan J.A.
        • Pollack M.M.
        Morbidity: changing the outcome paradigm for pediatric critical care.
        Pediatr Clin North Am. 2017; 64: 1147-1165
        • Manning J.C.
        • Pinto N.P.
        • Rennick J.E.
        • et al.
        Conceptualizing post intensive care syndrome in children-the PICS-p framework.
        Pediatr Crit Care Med. 2018; https://doi.org/10.1097/pcc.0000000000001476
        • Needham D.M.
        • Davidson J.
        • Cohen H.
        • et al.
        Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference.
        Crit Care Med. 2012; 40: 502-509
        • Long D.A.
        • Fink E.L.
        Transitions from short to long-term outcomes in pediatric critical care: considerations for clinical practice.
        Transl Pediatr. 2021; 10: 2858-2874
        • Ong C.
        • Lee J.H.
        • Leow M.K.
        • et al.
        Functional outcomes and physical impairments in pediatric critical care survivors: a scoping review.
        Pediatr Crit Care Med. 2016; 17: e247-e259
        • Shapiro M.C.
        • Henderson C.M.
        • Hutton N.
        • et al.
        Defining pediatric chronic critical illness for clinical care, research, and policy.
        Hosp Pediatr. 2017; 7: 236-244
        • Fiser D.H.
        Assessing the outcome of pediatric intensive care.
        J Pediatr. 1992; 121: 68-74
        • Pollack M.M.
        • Holubkov R.
        • Glass P.
        • et al.
        Functional Status Scale: new pediatric outcome measure.
        Pediatrics. 2009; 124: e18-e28
        • Stein R.E.
        • Jessop D.J.
        Functional status II(R). A measure of child health status.
        Med Care. 1990; 28: 1041-1055
        • Choong K.
        • Fraser D.
        • Al-Harbi S.
        • et al.
        Functional recovery in critically ill children, the "WeeCover" multicenter study.
        Pediatr Crit Care Med. 2018; 19: 145-154
        • Sankar J.
        • Moodu S.
        • Kumar K.
        • et al.
        Functional outcomes at 1 year after PICU discharge in critically ill children with severe sepsis.
        Pediatr Crit Care Med. 2021; 22: 40-49
        • Polic B.
        • Mestrovic J.
        • Markic J.
        • et al.
        Long-term quality of life of patients treated in paediatric intensive care unit.
        Eur J Pediatr. 2013; 172: 85-90
        • Herrup E.A.
        • Wieczorek B.
        • Kudchadkar S.R.
        Characteristics of postintensive care syndrome in survivors of pediatric critical illness: a systematic review.
        World J Crit Care Med. 2017; 6: 124-134
        • van der Heide P.
        • Hassing M.B.
        • Gemke R.J.
        Characteristics and outcome of long-stay patients in a paediatric intensive care unit: a case-control study.
        Acta Paediatr. 2004; 93: 1070-1074
        • Butt W.
        • Shann F.
        • Tibballs J.
        • et al.
        Long-term outcome of children after intensive care.
        Crit Care Med. 1990; 18: 961-965
        • Taylor A.
        • Butt W.
        • Ciardulli M.
        The functional outcome and quality of life of children after admission to an intensive care unit.
        Intensive Care Med. 2003; 29: 795-800
        • Namachivayam P.
        • Taylor A.
        • Montague T.
        • et al.
        Long-stay children in intensive care: long-term functional outcome and quality of life from a 20-yr institutional study.
        Pediatr Crit Care Med. 2012; 13: 520-528
        • Conlon N.P.
        • Breatnach C.
        • O'Hare B.P.
        • et al.
        Health-related quality of life after prolonged pediatric intensive care unit stay.
        Pediatr Crit Care Med. 2009; 10: 41-44
        • Varni J.W.
        • Seid M.
        • Kurtin P.S.
        PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations.
        Med Care. 2001; 39: 800-812
        • Jennett B.
        • Bond M.
        Assessment of outcome after severe brain damage.
        Lancet. 1975; 1: 480-484
        • Feeny D.H.
        • Torrance G.W.
        • Furlong W.J.
        Health utilities index.
        in: Spilker B. Qual life pharmacoeconomics in clin trials. 2nd edition. 26. Lippincott-Raven Press, Philadelphia, PA1996: 239-252
        • Bossen D.
        • de Boer R.M.
        • Knoester H.
        • et al.
        Physical functioning after admission to the PICU: a scoping review.
        Crit Care Explor. 2021; 3: e0462
        • Maddux A.B.
        • Pinto N.
        • Fink E.L.
        • et al.
        Postdischarge Outcome domains in pediatric critical care and the instruments used to evaluate them: a scoping review.
        Crit Care Med. 2020; 48: e1313-e1321
        • Murphy Salem S.
        • Graham R.J.
        Chronic illness in pediatric critical care.
        Front Pediatr. 2021; 9: 686206
        • Meert K.L.
        • Reeder R.
        • Maddux A.B.
        • et al.
        Trajectories and risk factors for altered physical and psychosocial health-related quality of life after pediatric community-acquired septic shock.
        Pediatr Crit Care Med. 2020; 21: 869-878
        • Zimmerman J.J.
        • Banks R.
        • Berg R.A.
        • et al.
        Trajectory of mortality and health-related quality of life morbidity following community-acquired pediatric septic shock.
        Crit Care Med. 2020; 48: 329-337
        • Hartman M.E.
        • Williams C.N.
        • Hall T.A.
        • et al.
        Post-Intensive-Care Syndrome for the pediatric neurologist.
        Pediatr Neurol. 2020; 108: 47-53
        • Smith M.B.
        • Killien E.Y.
        • Dervan L.A.
        • et al.
        The association of severe pain experienced in the pediatric intensive care unit and postdischarge health-related quality of life: a retrospective cohort study.
        Paediatr Anaesth. 2022; https://doi.org/10.1111/pan.14460
        • Stevens B.J.
        • Abbott L.K.
        • Yamada J.
        • et al.
        Epidemiology and management of painful procedures in children in Canadian hospitals.
        CMAJ. 2011; 183: E403-E410
        • Baarslag M.A.
        • Jhingoer S.
        • Ista E.
        • et al.
        How often do we perform painful and stressful procedures in the paediatric intensive care unit? A prospective observational study.
        Aust Crit Care. 2019; 32: 4-10
        • LaFond C.M.
        • Hanrahan K.S.
        • Pierce N.L.
        • et al.
        Pain in the pediatric intensive care unit: how and what are we doing?.
        Am J Crit Care. 2019; 28: 265-273
        • Kudchadkar S.R.
        • Aljohani O.A.
        • Punjabi N.M.
        Sleep of critically ill children in the pediatric intensive care unit: a systematic review.
        Sleep Med Rev. 2014; 18: 103-110
        • Berger J.
        • Zaidi M.
        • Halferty I.
        • et al.
        Sleep in the hospitalized child: a contemporary review.
        Chest. 2021; https://doi.org/10.1016/j.chest.2021.04.024
        • Barnes S.S.
        • Kudchadkar S.R.
        Sedative choice and ventilator-associated patient outcomes: don't sleep on delirium.
        Ann Transl Med. 2016; 4: 34
        • Dervan L.A.
        • Wrede J.E.
        • Watson R.S.
        Sleep architecture in mechanically ventilated pediatric ICU patients receiving goal-directed, dexmedetomidine- and opioid-based sedation.
        J Pediatr Intensive Care. 2022; 11: 32-40
        • Freedman N.S.
        • Gazendam J.
        • Levan L.
        • et al.
        Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit.
        Am J Respir Crit Care Med. 2001; 163: 451-457
        • Als L.C.
        • Picouto M.D.
        • Hau S.M.
        • et al.
        Mental and physical well-being following admission to pediatric intensive care.
        Pediatr Crit Care Med. 2015; 16: e141-e149
        • National Institute of Aging
        Cognitive health and older adults.
        (Available at:) (Accessed June 6, 2022)
        • Woodruff A.G.
        • Choong K.
        Long-term outcomes and the post-intensive care syndrome in critically ill children: a North American perspective.
        Child (Basel). 2021; 8https://doi.org/10.3390/children8040254
        • Watson R.S.
        • Beers S.R.
        • Asaro L.A.
        • et al.
        Association of acute respiratory failure in early childhood with long-term neurocognitive outcomes.
        JAMA. 2022; 327: 836-845
        • Bone M.F.
        • Feinglass J.M.
        • Goodman D.M.
        Risk factors for acquiring functional and cognitive disabilities during admission to a PICU.
        Pediatr Crit Care Med. 2014; 15: 640-648
        • Madurski C.
        • Treble-Barna A.
        • Fink E.L.
        Cognitive impairment following pediatric critical illness: time to pay attention.
        Pediatr Crit Care Med. 2018; 19: 277-278
        • Kachmar A.G.
        • Irving S.Y.
        • Connolly C.A.
        • et al.
        A systematic review of risk factors associated with cognitive impairment after pediatric critical illness.
        Pediatr Crit Care Med. 2018; 19: e164-e171
        • Baron I.S.
        • Weiss B.A.
        • Litman F.R.
        • et al.
        Latent mean differences in executive function in at-risk preterm children: the delay-deficit dilemma.
        Neuropsychol. 2014; 28: 541-551
        • Aarsen F.K.
        • Paquier P.F.
        • Reddingius R.E.
        • et al.
        Functional outcome after low-grade astrocytoma treatment in childhood.
        Cancer. 2006; 106: 396-402
        • van Houdt C.A.
        • Oosterlaan J.
        • van Wassenaer-Leemhuis A.G.
        • et al.
        Executive function deficits in children born preterm or at low birthweight: a meta-analysis.
        Dev Med Child Neurol. 2019; 61: 1015-1024
        • Block R.I.
        • Thomas J.J.
        • Bayman E.O.
        • et al.
        Are anesthesia and surgery during infancy associated with altered academic performance during childhood?.
        Anesthesiology. 2012; 117: 494-503
        • Mody K.
        • Kaur S.
        • Mauer E.A.
        • et al.
        Benzodiazepines and development of delirium in critically ill children: estimating the causal effect.
        Crit Care Med. 2018; 46: 1486-1491
        • Girard T.D.
        • Jackson J.C.
        • Pandharipande P.P.
        • et al.
        Delirium as a predictor of long-term cognitive impairment in survivors of critical illness.
        Crit Care Med. 2010; 38: 1513-1520
        • Mart M.F.
        • Williams Roberson S.
        • Salas B.
        • et al.
        Prevention and management of delirium in the intensive care unit.
        Semin Respir Crit Care Med. 2021; 42: 112-126
        • Pandharipande P.P.
        • Girard T.D.
        • Jackson J.C.
        • et al.
        Long-term cognitive impairment after critical illness.
        N Engl J Med. 2013; 369: 1306-1316
        • Als L.C.
        • Nadel S.
        • Cooper M.
        • et al.
        Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children.
        Crit Care Med. 2013; 41: 1094-1103
        • Christie D.
        • Rashid H.
        • El-Bashir H.
        • et al.
        Impact of meningitis on intelligence and development: a systematic review and meta-analysis.
        PLoS One. 2017; 12: e0175024
        • National Institutes of Health
        Emotional wellness toolkit. NIH.
        (Available at:) (Accessed June 7, 2022)
        • Nelson L.P.
        • Gold J.I.
        Posttraumatic stress disorder in children and their parents following admission to the pediatric intensive care unit: a review.
        Pediatr Crit Care Med. 2012; 13: 338-347
        • Nelson L.P.
        • Lachman S.E.
        • Goodman K.
        • et al.
        Admission psychosocial characteristics of critically ill children and acute stress.
        Pediatr Crit Care Med. 2021; 22: 194-203
        • Davydow D.S.
        • Richardson L.P.
        • Zatzick D.F.
        • et al.
        Psychiatric morbidity in pediatric critical illness survivors: a comprehensive review of the literature.
        Arch Pediatr Adolesc Med. 2010; 164: 377-385
        • O'Meara A.
        • Akande M.
        • Yagiela L.
        • et al.
        Family outcomes after the pediatric intensive care unit: a scoping review.
        J Intensive Care Med. 2021; (8850666211056603)
        • Terp K.
        • Sjöström-Strand A.
        Parents' experiences and the effect on the family two years after their child was admitted to a PICU-An interview study.
        Intensive Crit Care Nurs. 2017; 43: 143-148
        • Epstein D.
        • Reibel M.
        • Unger J.B.
        • et al.
        The effect of neighborhood and individual characteristics on pediatric critical illness.
        J Community Health. 2014; 39: 753-759
        • Kachmar A.G.
        • Watson R.S.
        • Wypij D.
        • et al.
        • the RESTORE Investigative Team
        Association of socioeconomic status with postdischarge pediatric resource use and quality of life.
        Crit Care Med. 2022; 50: e117-e128
        • Als L.C.
        • Nadel S.
        • Cooper M.
        • et al.
        A supported psychoeducational intervention to improve family mental health following discharge from paediatric intensive care: feasibility and pilot randomised controlled trial.
        BMJ Open. 2015; 5: e009581
        • Coville G.
        • Cream P.
        Post-traumatic growth in parents after a child's admission to intensive care: maybe Nietzsche was right?.
        Intensive Care Med. 2009; 35: 919-923
        • Cobb A.R.
        • Tedeschi R.G.
        • Calhoun L.G.
        • et al.
        Correlates of posttraumatic growth in survivors of intimate partner violence.
        J Trauma Stress. 2006; 19: 895-903
        • Cryder C.H.
        • Kilmer R.P.
        • Tedeschi R.G.
        • et al.
        An exploratory study of posttraumatic growth in children following a natural disaster.
        Am J Orthopsychiatry. 2006; 76: 65-69
        • Zamora E.R.
        • Yi J.
        • Akter J.
        • et al.
        Having cancer was awful but also something good came out': post-traumatic growth among adult survivors of pediatric and adolescent cancer.
        Eur J Oncol Nurs. 2017; 28: 21-27
        • Tedeschi R.G.
        • Calhoun L.G.
        The Posttraumatic Growth Inventory: measuring the positive legacy of trauma.
        J Trauma Stress. 1996; 9: 455-471
        • Rodríguez-Rey R.
        • Alonso-Tapia J.
        Predicting posttraumatic growth in mothers and fathers of critically ill children: a longitudinal study.
        J Clin Psychol Med Settings. 2019; 26: 372-381
        • Daughtrey H.
        • Slain K.N.
        • Derrington S.
        • et al.
        Measuring social health following pediatric critical illness: a scoping review and conceptual framework.
        J Intensive Care Med. 2022; 22 (8850666221102815)
        • Rennick J.E.
        • McHarg L.F.
        • Dell'Api M.
        • et al.
        Developing the Children's Critical Illness Impact Scale: capturing stories from children, parents, and staff.
        Pediatr Crit Care Med. 2008; 9: 252-260
        • Manning J.C.
        • Hemingway P.
        • Redsell S.A.
        Stories of survival: children's narratives of psychosocial well-being following paediatric critical illness or injury.
        J Child Health Care. 2017; 21: 236-252
        • Kastner K.
        • Pinto N.
        • Msall M.E.
        • et al.
        PICU follow-up: the impact of missed school in a cohort of children following PICU admission.
        Crit Care Explor. 2019; 1: e0033
        • Carlton E.F.
        • Donnelly J.P.
        • Prescott H.C.
        • et al.
        School and work absences after critical care hospitalization for pediatric acute respiratory failure: a secondary analysis of a cluster randomized trial.
        JAMA Netw Open. 2021; 4: e2140732
        • Colville G.A.
        • Pierce C.M.
        Children's self-reported quality of life after intensive care treatment.
        Pediatr Crit Care Med. 2013; 14: e85-e92
        • Tomaszewski W.
        • Ablaza C.
        • Straney L.
        • et al.
        Educational outcomes of childhood survivors of critical illness-a population-based linkage study.
        Crit Care Med. 2022; 50: 901-912
        • Clark M.E.
        • Cummings B.M.
        • Kuhlthau K.
        • et al.
        Impact of Pediatric intensive care unit admission on family financial status and productivity: a pilot study.
        J Intensive Care Med. 2019; 34: 973-977
        • Ducharme-Crevier L.
        • La K.A.
        • Francois T.
        • et al.
        PICU follow-up clinic: patient and family outcomes 2 months after discharge.
        Pediatr Crit Care Med. 2021; 22: 935-943
        • Grandjean C.
        • Ullmann P.
        • Marston M.
        • et al.
        Sources of stress, family functioning, and needs of families with a chronic critically ill child: a qualitative study.
        Front Pediatr. 2021; 9: 740598
        • Brown R.T.
        • Wiener L.
        • Kupst M.J.
        • et al.
        Single parents of children with chronic illness: an understudied phenomenon.
        J Pediatr Psychol. 2008; 33: 408-421
        • Abela K.M.
        • Casarez R.L.
        • Kaplow J.
        • et al.
        Siblings' experience during pediatric intensive care hospitalization.
        J Pediatr Nurs. 2022; 64: 111-118
        • Abela K.M.
        • Wardell D.
        • Rozmus C.
        • et al.
        Impact of pediatric critical illness and injury on families: an updated systematic review.
        J Pediatr Nurs. 2020; 51: 21-31
        • Rozdilsky J.R.
        Enhancing sibling presence in pediatric ICU.
        Crit Care Nurs Clin North Am. 2005; 17: 451-461, xii
        • Deavin A.
        • Greasley P.
        • Dixon C.
        Children's perspectives on living with a sibling with a chronic illness.
        Pediatrics. 2018; 142https://doi.org/10.1542/peds.2017-4151
        • Havill N.
        • Fleming L.K.
        • Knafl K.
        Well siblings of children with chronic illness: a synthesis research study.
        Res Nurs Health. 2019; 42: 334-348
        • Manning J.C.
        • Latour J.M.
        • Curley M.A.Q.
        • et al.
        Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study.
        BMJ Open. 2020; 10: e038974
        • Williamson P.R.
        • Altman D.G.
        • Blazeby J.M.
        • et al.
        Developing core outcome sets for clinical trials: issues to consider.
        Trials. 2012; 13: 132
        • Williamson P.R.
        • Altman D.G.
        • Bagley H.
        • et al.
        The COMET Handbook: version 1.0.
        Trials. 2017; 18: 280
        • Pinto N.P.
        • Maddux A.B.
        • Dervan L.A.
        • et al.
        • POST-PICU Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
        • The Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)
        A core outcome measurement set for pediatric critical care.
        Pediatr Crit Care Med. 2022; (Epub ahead of print)https://doi.org/10.1097/PCC.0000000000003055
      1. The virtual PICU system, LLC.
        (Available at:) (Accessed April 5, 2022)
        • Wetzel R.C.
        Pediatric intensive care databases for quality improvement.
        J Pediatr Intensive Care. 2016; 5: 81-88
        • Kids A.H.R.Q.
        Inpatient database (KID) database documentation.
        (Available at:)
      2. PICANet.
        (Available at:) (Accessed April 24, 2022)
        • Rousseau A.F.
        • Prescott H.C.
        • Brett S.J.
        • et al.
        Long-term outcomes after critical illness: recent insights.
        Crit Care. 2021; 25: 108
        • Mayer K.P.
        • Parry S.M.
        • Kalema A.G.
        • et al.
        Safety and feasibility of an interdisciplinary treatment approach to optimize recovery from critical Coronavirus Disease 2019.
        Crit Care Explor. 2021; 3: e0516
        • Bloom S.L.
        • Stollings J.L.
        • Kirkpatrick O.
        • et al.
        Randomized clinical trial of an icu recovery pilot program for survivors of critical illness.
        Crit Care Med. 2019; 47: 1337-1345
        • Teixeira C.
        • Rosa R.G.
        Post-intensive care outpatient clinic: is it feasible and effective? A literature review.
        Rev Bras Ter Intensiva. 2018; 30: 98-111
        • McPeake J.
        • Hirshberg E.L.
        • Christie L.M.
        • et al.
        Models of peer support to remediate post-intensive care syndrome: a report developed by the Society of Critical Care Medicine Thrive International peer support collaborative.
        Crit Care Med. 2019; 47: e21-e27
        • Haines K.J.
        • Sevin C.M.
        • Hibbert E.
        • et al.
        Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives.
        Intensive Care Med. 2019; 45: 939-947
        • Manning J.C.
        • Scholefield B.R.
        • Popejoy E.
        • et al.
        Paediatric intensive care follow-up provision in the United Kingdom and Republic of Ireland.
        Nurs Crit Care. 2021; 26: 128-134
        • Fitzgerald J.C.
        • Kelly N.A.
        • Hickey C.
        • et al.
        Implementation of a follow-up system for pediatric sepsis survivors in a large academic Pediatric Intensive Care Unit.
        Front Pediatr. 2021; 9: 691692
        • Williams C.N.
        • Hall T.A.
        • Francoeur C.
        • et al.
        Continuing care for critically ill children beyond hospital discharge: current state of follow-up.
        Hosp Pediatr. 2022; 12: 359-393
        • Marra A.
        • Ely E.W.
        • Pandharipande P.P.
        • et al.
        The ABCDEF Bundle in critical care.
        Crit Care Clin. 2017; 33: 225-243
        • Lee Y.
        • Kim K.
        • Lim C.
        • et al.
        Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: a retrospective study.
        J Adv Nurs. 2020; 76: 588-599
        • Ista E.
        • Redivo J.
        • Kananur P.
        • et al.
        ABCDEF bundle practices for critically ill children: an international survey of 161 PICUs in 18 countries.
        Crit Care Med. 2022; 50: 114-125
        • Wieczorek B.
        • Ascenzi J.
        • Kim Y.
        • et al.
        PICU Up!: impact of a quality improvement intervention to promote early mobilization in critically ill children.
        Pediatr Crit Care Med. 2016; 17: e559-e566
        • Choong K.
        • Abu-Sultaneh S.
        Applying the ICU liberation bundle to critically ill children.
        (Available at:) (Accessed August 11, 2021)